Appropriate subcellular localization is crucial for regulating p53 function. We show that p53
export is mediated by a highly conserved leucine-rich nuclear export signal (NES) located in …

Background A pandemic H5N1 influenza outbreak would be facilitated by an absence of
immunity to the avian-derived virus in the human population. Although this condition is likely in …

p53 activation by diverse stresses involves post-translational modifications that alter its
structure and result in its nuclear accumulation. We will discuss several unresolved topics …

The gene Trp53 is among the most frequently mutated and studied genes in human cancer,
but the mechanisms by which it suppresses tumour formation remain unclear. We generated …

Next generation influenza vaccines containing conserved antigens may enhance immunity
against seasonal or pandemic influenza virus strains. Using a plasmid DNA (pDNA)-based …

Damage to DNA in the cell activates the tumour-suppressor protein p53 ( 1 ), and failure of
this activation leads to genetic instability and a predisposition to cancer. It is therefore crucial …

The fission yeast Schizosaccharomyces pombe and the budding yeast Saccharomyces
cerevisiae have become valuable tools for the study of basic cellular functions of eukaryotic cells…

A measles virus vaccine for infants under 6 months of age would help control measles. DNA
vaccines hold promise, but none has provided full protection from challenge. Codon-…

The CD30 transmembrane receptor from the tumor necrosis factor receptor family is expressed
in a distinct, yet diverse set of lymphoproliferative disorders and a small subset of normal …

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