Novel effects of nitric oxide

KL Davis, E Martin, IV Turko… - Annual review of …, 2001 - annualreviews.org
Nitric oxide (NO), a simple free radical gas, elicits a surprisingly wide range of physiological
and pathophysiological effects. NO interacts with soluble guanylate cyclase to evoke many …

Cyclic nucleotide phosphodiesterases: relating structure and function

SH Francis, IV Turko, JD Corbin - 2000 - Elsevier
Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of metallophosphohydrolases
that specifically cleave the 3′, 5′-cyclic phosphate moiety of cAMP and/or eGMP …

Protein nitration in cardiovascular diseases

IV Turko, F Murad - Pharmacological reviews, 2002 - ASPET
There is growing evidence that cardiovascular disease is associated with progressive
changes in the production of free radicals and radical-derived reactive species. These …

Phosphorylation of phosphodiesterase‐5 by cyclic nucleotide‐dependent protein kinase alters its catalytic and allosteric cGMP‐binding activities

JD Corbin, IV Turko, A Beasley… - European Journal of …, 2000 - Wiley Online Library
In addition to its cGMP‐selective catalytic site, cGMP‐binding cGMP‐specific phosphodiesterase
(PDE5) contains two allosteric cGMP‐binding sites and at least one phosphorylation …

Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds

IV Turko, SA Ballard, SH Francis, JD Corbin - Molecular Pharmacology, 1999 - ASPET
The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates
the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus …

Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA: 3-oxoacid CoA-transferase

IV Turko, S Marcondes, F Murad - American Journal of …, 2001 - journals.physiology.org
High levels of reactive species of nitrogen and oxygen in diabetes may cause modifications
of proteins. Recently, an increase in protein tyrosine nitration was found in several diabetic …

[HTML][HTML] Protein tyrosine nitration in the mitochondria from diabetic mouse heart: implications to dysfunctional mitochondria in diabetes

IV Turko, L Li, KS Aulak, DJ Stuehr, JY Chang… - Journal of Biological …, 2003 - ASBMB
Oxidative stress has been implicated in dysfunctional mitochondria in diabetes. Tyrosine
nitration of mitochondrial proteins was observed under conditions of oxidative stress. We …

[HTML][HTML] Quantitative protein profiling in heart mitochondria from diabetic rats

IV Turko, F Murad - Journal of Biological Chemistry, 2003 - ASBMB
Quantitative protein profiling based on in vitro stable isotope labeling, two-dimensional
polyacrylamide gel electrophoresis, and mass spectrometry is an accurate and reliable approach …

[HTML][HTML] QUANTITY: an isobaric tag for quantitative glycomics

S Yang, M Wang, L Chen, B Yin, G Song, IV Turko… - Scientific reports, 2015 - nature.com
Glycan is an important class of macromolecules that play numerous biological functions.
Quantitative glycomics - analysis of glycans at global level - however, is far behind genomics …

[HTML][HTML] Structural basis for inactivation of Giardia lamblia carbamate kinase by disulfiram

…, K Lim, CZ Chen, W Zheng, IV Turko… - Journal of Biological …, 2014 - ASBMB
Carbamate kinase from Giardia lamblia is an essential enzyme for the survival of the organism.
The enzyme catalyzes the final step in the arginine dihydrolase pathway converting ADP …