Novel effects of nitric oxide
KL Davis, E Martin, IV Turko… - Annual review of …, 2001 - annualreviews.org
Nitric oxide (NO), a simple free radical gas, elicits a surprisingly wide range of physiological
and pathophysiological effects. NO interacts with soluble guanylate cyclase to evoke many …
and pathophysiological effects. NO interacts with soluble guanylate cyclase to evoke many …
Cyclic nucleotide phosphodiesterases: relating structure and function
SH Francis, IV Turko, JD Corbin - 2000 - Elsevier
Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of metallophosphohydrolases
that specifically cleave the 3′, 5′-cyclic phosphate moiety of cAMP and/or eGMP …
that specifically cleave the 3′, 5′-cyclic phosphate moiety of cAMP and/or eGMP …
Protein nitration in cardiovascular diseases
IV Turko, F Murad - Pharmacological reviews, 2002 - ASPET
There is growing evidence that cardiovascular disease is associated with progressive
changes in the production of free radicals and radical-derived reactive species. These …
changes in the production of free radicals and radical-derived reactive species. These …
Phosphorylation of phosphodiesterase‐5 by cyclic nucleotide‐dependent protein kinase alters its catalytic and allosteric cGMP‐binding activities
JD Corbin, IV Turko, A Beasley… - European Journal of …, 2000 - Wiley Online Library
In addition to its cGMP‐selective catalytic site, cGMP‐binding cGMP‐specific phosphodiesterase
(PDE5) contains two allosteric cGMP‐binding sites and at least one phosphorylation …
(PDE5) contains two allosteric cGMP‐binding sites and at least one phosphorylation …
Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds
IV Turko, SA Ballard, SH Francis, JD Corbin - Molecular Pharmacology, 1999 - ASPET
The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates
the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus …
the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus …
Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA: 3-oxoacid CoA-transferase
IV Turko, S Marcondes, F Murad - American Journal of …, 2001 - journals.physiology.org
High levels of reactive species of nitrogen and oxygen in diabetes may cause modifications
of proteins. Recently, an increase in protein tyrosine nitration was found in several diabetic …
of proteins. Recently, an increase in protein tyrosine nitration was found in several diabetic …
[HTML][HTML] Protein tyrosine nitration in the mitochondria from diabetic mouse heart: implications to dysfunctional mitochondria in diabetes
IV Turko, L Li, KS Aulak, DJ Stuehr, JY Chang… - Journal of Biological …, 2003 - ASBMB
Oxidative stress has been implicated in dysfunctional mitochondria in diabetes. Tyrosine
nitration of mitochondrial proteins was observed under conditions of oxidative stress. We …
nitration of mitochondrial proteins was observed under conditions of oxidative stress. We …
[HTML][HTML] Quantitative protein profiling in heart mitochondria from diabetic rats
IV Turko, F Murad - Journal of Biological Chemistry, 2003 - ASBMB
Quantitative protein profiling based on in vitro stable isotope labeling, two-dimensional
polyacrylamide gel electrophoresis, and mass spectrometry is an accurate and reliable approach …
polyacrylamide gel electrophoresis, and mass spectrometry is an accurate and reliable approach …
[HTML][HTML] QUANTITY: an isobaric tag for quantitative glycomics
S Yang, M Wang, L Chen, B Yin, G Song, IV Turko… - Scientific reports, 2015 - nature.com
Glycan is an important class of macromolecules that play numerous biological functions.
Quantitative glycomics - analysis of glycans at global level - however, is far behind genomics …
Quantitative glycomics - analysis of glycans at global level - however, is far behind genomics …
[HTML][HTML] Structural basis for inactivation of Giardia lamblia carbamate kinase by disulfiram
Carbamate kinase from Giardia lamblia is an essential enzyme for the survival of the organism.
The enzyme catalyzes the final step in the arginine dihydrolase pathway converting ADP …
The enzyme catalyzes the final step in the arginine dihydrolase pathway converting ADP …