A regulatory hierarchy for cell specialization in yeast

I Herskowitz - Nature, 1989 - nature.com
The specialized sets of genes that determine different cell types in yeast are controlled by
combinations of DNA-binding proteins some of which are present only in certain cell types …

The transcriptional program of sporulation in budding yeast

…, J Mulholland, D Botstein, PO Brown, I Herskowitz - Science, 1998 - science.org
Diploid cells of budding yeast produce haploid cells through the developmental program of
sporulation, which consists of meiosis and spore morphogenesis. DNA microarrays …

Life cycle of the budding yeast Saccharomyces cerevisiae

I Herskowitz - Microbiological reviews, 1988 - Am Soc Microbiol
The purpose of this article is to review essential features of the life cycle of the budding yeast
Saccharomyces cerevisiae as a starting point for learning about S. cerevisiae and its cell …

Five SWI genes are required for expression of the HO gene in yeast

M Stern, R Jensen, I Herskowitz - Journal of molecular biology, 1984 - Elsevier
High-frequency mating type interconversion in yeast requires the HO gene, which encodes
a site-specific endonuclease that initiates the switching process. We have isolated and …

Functional inactivation of genes by dominant negative mutations

I Herskowitz - Nature, 1987 - nature.com
Molecular biologists are increasingly faced with the problem of assigning a function to genes
that have been cloned. A new approach to this problem involves the manipulation of the …

MAP kinase pathways in yeast: for mating and more

I Herskowitz - Cell, 1995 - Elsevier
… the filamentous form after mating (Banuett and Herskowitz, 1994a, 1994b). An unanticipated …
competence for tumor formation (Banuett and Herskowitz, 1994a). These studies offer a first …

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

…, J Lee, DJ Thiele, I Herskowitz - Proceedings of the …, 2002 - National Acad Sciences
Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and
acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. Molecular mechanisms …

Four Genes Responsible for a Position Effect on Expression From HML and HMR in Saccharomyces cerevisiae

J Rine, I Herskowitz - Genetics, 1987 - academic.oup.com
Mating type interconversion in Saccharomyces cerevisiae occurs by transposition of copies
of the a or α mating type cassettes from inactive loci, HML and HMR, to an active locus, MAT. …

Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription

CL Peterson, I Herskowitz - Cell, 1992 - Elsevier
The yeast SWI1, SWI2 (SNF2), and SWI3 genes are required for transcription of HO and INO1
genes. We show that they are also required for transcription of ADH1, ADH2, SUC2, GAL1, …

Structure of a yeast pheromone gene (MFα): a putative α-factor precursor contains four tandem copies of mature α-factor

J Kurjan, I Herskowitz - Cell, 1982 - cell.com
We have cloned and sequenced a gene (M&x) coding for a-factor, a tridecapeptide mating
factor secreted by yeast a! cells. A plasmid carrying the MFcw gene was identified by …