Background The mechanism of action of the novel antidepressant bupropion remains unclear
after many years of study. A review of the relevant biochemical, in vivo brain microdialysis, …

A comment on this article appears in" Fluoxetine and suicidal preoccupation." Am J Psychiatry.
1992 Dec; 149 (12): 1750. A comment on this article appears in" Media coverage versus …

Welcome to the fifth edition of a very handy and useful book, the Manual of Clinical
Psychopharmacology. Readers familiar with any of the previous editions are already aware of 2 …

Opiates were used to treat major depression until the mid-1950s. The advent of opioids with
mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse …

Background Although growing research indicates that the atypical antipsychotic agent clozapine
is effective in patients with schizophrenia, little is known about the efficacy of clozapine …

Objective This review explores the theoretical background for and empirical evidence
supporting gender-related differences in pharmacokinetics and pharmacodynamic properties of …

In recent years, considerable data have emerged that psychotic (delusional) depression is
characterized by pronounced increases in hypothalamic-pituitary-adrenal (HPA) axis activity …

Our review of the studies of clinical efficacy of the tricyclic compounds in the treatment of
depression supports the general view that imipramine and amitriptyline are more effective than …

Background Clozapine has been increasingly shown to be effective in the acute and maintenance
treatment of bipolar disorders. For this reason, we studied whether clozapine alone is …

Although antidepressant medications represent the cornerstone of treatment for patients
with moderate to severe clinical depression, they also carry serious risks. There is evidence …