User profiles for Jacob Eriksen
 | Jacob EriksenNine Square Therapeutics Verified email at ninesquaretx.com Cited by 2065 |
SLC6 neurotransmitter transporters: structure, function, and regulation
…, TN Jørgensen, L Sørensen, J Eriksen… - Pharmacological …, 2011 - ASPET
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na + /Cl − -dependent …
family (also referred to as the neurotransmitter-sodium-symporter family or Na + /Cl − -dependent …
Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after …
EM Adkins, DJ Samuvel, JU Fog, J Eriksen… - Biochemistry, 2007 - ACS Publications
To investigate microdomain association of the dopamine transporter (DAT), we employed
FCS (fluorescence correlation spectroscopy) and FRAP (fluorescence recovery after …
FCS (fluorescence correlation spectroscopy) and FRAP (fluorescence recovery after …
Regulation of dopamine transporter function by protein‐protein interactions: new discoveries and methodological challenges
J. Neurochem. (2010) 10.1111/j.1471‐4159.2010.06599.x Abstract The dopamine transporter
(DAT) plays a key role in regulating dopaminergic signalling in the brain by mediating …
(DAT) plays a key role in regulating dopaminergic signalling in the brain by mediating …
Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs
J Eriksen, SGF Rasmussen… - Journal of …, 2009 - Soc Neuroscience
The dopamine transporter (DAT) mediates reuptake of dopamine from the synaptic cleft and
is a target for widely abused psychostimulants such as cocaine and amphetamine. …
is a target for widely abused psychostimulants such as cocaine and amphetamine. …
[HTML][HTML] Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
Dopamine regulates reward, cognition, and locomotor functions. By mediating rapid reuptake
of extracellular dopamine, the dopamine transporter is critical for spatiotemporal control of …
of extracellular dopamine, the dopamine transporter is critical for spatiotemporal control of …
[PDF][PDF] Synaptic vesicle recycling pathway determines neurotransmitter content and release properties
In contrast to temporal coding by synaptically acting neurotransmitters such as glutamate,
neuromodulators such as monoamines signal changes in firing rate. The two modes of …
neuromodulators such as monoamines signal changes in firing rate. The two modes of …
[PDF][PDF] Protons regulate vesicular glutamate transporters through an allosteric mechanism
The quantal nature of synaptic transmission requires a mechanism to transport neurotransmitter
into synaptic vesicles without promoting non-vesicular efflux across the plasma …
into synaptic vesicles without promoting non-vesicular efflux across the plasma …
Ion transport and regulation in a synaptic vesicle glutamate transporter
Synaptic vesicles accumulate neurotransmitters, enabling the quantal release by exocytosis
that underlies synaptic transmission. Specific neurotransmitter transporters are responsible …
that underlies synaptic transmission. Specific neurotransmitter transporters are responsible …
[HTML][HTML] Structures suggest a mechanism for energy coupling by a family of organic anion transporters
Members of the solute carrier 17 (SLC17) family use divergent mechanisms to concentrate
organic anions. Membrane potential drives uptake of the principal excitatory neurotransmitter …
organic anions. Membrane potential drives uptake of the principal excitatory neurotransmitter …
Adaptor protein-3 produces synaptic vesicles that release phasic dopamine
The burst firing of midbrain dopamine neurons releases a phasic dopamine signal that
mediates reinforcement learning. At many synapses, however, high firing rates deplete synaptic …
mediates reinforcement learning. At many synapses, however, high firing rates deplete synaptic …