User profiles for James B. Koprich
 | James KoprichChief Scientific Officer, Atuka Inc. Verified email at atuka.com Cited by 4075 |
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV α …
CY Chung, JB Koprich, H Siddiqi… - Journal of …, 2009 - Soc Neuroscience
Little is known about key pathological events preceding overt neuronal degeneration in
Parkinson's disease (PD) and α-synucleinopathy. Recombinant adeno-associated virus 2-…
Parkinson's disease (PD) and α-synucleinopathy. Recombinant adeno-associated virus 2-…
[HTML][HTML] Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
JB Koprich, C Reske-Nielsen, P Mithal… - Journal of …, 2008 - Springer
Background The etiology of Parkinson's disease (PD) remains elusive despite identification
of several genetic mutations. It is more likely that multiple factors converge to give rise to PD …
of several genetic mutations. It is more likely that multiple factors converge to give rise to PD …
The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease
l-3,4-Dihydroxyphenylalanine (l-DOPA) remains the most effective symptomatic treatment of
Parkinson’s disease (PD). However, long-term administration of l-DOPA is marred by the …
Parkinson’s disease (PD). However, long-term administration of l-DOPA is marred by the …
Animal models of α-synucleinopathy for Parkinson disease drug development
JB Koprich, LV Kalia, JM Brotchie - Nature Reviews Neuroscience, 2017 - nature.com
A major challenge in Parkinson disease (PD) will be to turn an emerging and expanding
pipeline of novel disease-modifying candidate compounds into therapeutics. Novel targets …
pipeline of novel disease-modifying candidate compounds into therapeutics. Novel targets …
α-Synuclein-based animal models of Parkinson's disease: challenges and opportunities in a new era
In recent years, a new generation of animal models of Parkinson's disease (PD) based on
ectopic expression, overexpression, or intracerebral injection of the protein α-synuclein have …
ectopic expression, overexpression, or intracerebral injection of the protein α-synuclein have …
[HTML][HTML] Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein …
JB Koprich, TH Johnston, MG Reyes, X Sun… - Molecular …, 2010 - Springer
Background The pathological hallmarks of Parkinson's disease (PD) include the presence
of alpha-synuclein (α-syn) rich Lewy bodies and neurites and the loss of dopaminergic (DA) …
of alpha-synuclein (α-syn) rich Lewy bodies and neurites and the loss of dopaminergic (DA) …
[HTML][HTML] AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and …
α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson’s disease (PD).
AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey …
AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey …
Treatment with trehalose prevents behavioral and neurochemical deficits produced in an AAV α-synuclein rat model of Parkinson's disease
Q He, JB Koprich, Y Wang, W Yu, B Xiao… - Molecular …, 2016 - Springer
The accumulation of misfolded α-synuclein in dopamine (DA) neurons is believed to be of
major importance in the pathogenesis of Parkinson’s disease (PD). Animal models of PD, …
major importance in the pathogenesis of Parkinson’s disease (PD). Animal models of PD, …
[HTML][HTML] Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein
JB Koprich, TH Johnston, P Huot, MG Reyes… - PloS one, 2011 - journals.plos.org
The pathological hallmarks of Parkinson's disease (PD) are degeneration of dopamine (DA)
neurons of the substantia nigra (SN) and the presence of alpha-synuclein (α-syn)-rich Lewy …
neurons of the substantia nigra (SN) and the presence of alpha-synuclein (α-syn)-rich Lewy …
The Toll-like receptor-3 agonist polyinosinic: polycytidylic acid triggers nigrostriatal dopaminergic degeneration
M Deleidi, PJ Hallett, JB Koprich… - Journal of …, 2010 - Soc Neuroscience
In Parkinson's disease (PD), loss of striatal dopaminergic (DA) terminals and degeneration
of DA neurons in the substantia nigra (SN) are associated with glial reactions. Such …
of DA neurons in the substantia nigra (SN) are associated with glial reactions. Such …