User profiles for Jessica L. Ables

Jessica L. Ables, MD PhD

Icahn School of Medicine at Mount Sinai
Verified email at mssm.edu
Cited by 4198

Dynamic contribution of nestin-expressing stem cells to adult neurogenesis

…, MC Whitman, MA Noonan, JL Ables… - Journal of …, 2007 - Soc Neuroscience
Understanding the fate of adult-generated neurons and the mechanisms that influence them
requires consistent labeling and tracking of large numbers of stem cells. We generated a …

Not (ch) just development: Notch signalling in the adult brain

JL Ables, JJ Breunig, AJ Eisch, P Rakic - Nature Reviews …, 2011 - nature.com
The Notch pathway is often regarded as a developmental pathway, but components of
Notch signalling are expressed and active in the adult brain. With the advent of more …

Neurod1 is essential for the survival and maturation of adult-born neurons

Z Gao, K Ure, JL Ables, DC Lagace, KA Nave… - Nature …, 2009 - nature.com
The transcriptional program that controls adult neurogenesis is unknown. We generated
mice with an inducible stem cell–specific deletion of Neurod1, resulting in substantially fewer …

Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells

JL Ables, NA DeCarolis, MA Johnson… - Journal of …, 2010 - Soc Neuroscience
Notch1 regulates neural stem cell (NSC) number during development, but its role in adult
neurogenesis is unclear. We generated nestin-CreER T2 /R26R-YFP/Notch1 loxP/loxP […

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

…, K Davis, ME Cahill, C Dias, E Ribeiro, JL Ables… - Nature medicine, 2013 - nature.com
Depression induces structural and functional synaptic plasticity in brain reward circuits,
although the mechanisms promoting these changes and their relevance to behavioral outcomes …

Neurotrophic factors and structural plasticity in addiction

SJ Russo, MS Mazei-Robison, JL Ables, EJ Nestler - Neuropharmacology, 2009 - Elsevier
Drugs of abuse produce widespread effects on the structure and function of neurons
throughout the brain's reward circuitry, and these changes are believed to underlie the long-lasting …

IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity

…, V Krishnan, CM Reyes, MH Han, JL Ables… - Journal of …, 2011 - Soc Neuroscience
The neurobiological underpinnings of mood and anxiety disorders have been linked to the
nucleus accumbens (NAc), a region important in processing the rewarding and emotional …

[HTML][HTML] Ascl1 (Mash1) defines cells with long-term neurogenic potential in subgranular and subventricular zones in adult mouse brain

EJ Kim, JL Ables, LK Dickel, AJ Eisch, JE Johnson - PloS one, 2011 - journals.plos.org
Ascl1 (Mash1) is a bHLH transcription factor essential for neural differentiation during
embryogenesis but its role in adult neurogenesis is less clear. Here we show that in the adult brain …

AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli

…, MH Han, M Mazei-Robison, SD Iñiguez, JL Ables… - Biological …, 2008 - Elsevier
BACKGROUND: The neurobiological mechanisms by which only a minority of stress-exposed
individuals develop psychiatric diseases remain largely unknown. Recent evidence …

The habenulo-interpeduncular pathway in nicotine aversion and withdrawal

B Antolin-Fontes, JL Ables, A Görlich… - Neuropharmacology, 2015 - Elsevier
Progress has been made over the last decade in our understanding of the brain areas and
circuits involved in nicotine reward and withdrawal, leading to models of addiction that assign …