User profiles for John T. Williams

John T Williams

Oregon Health Sciences University
Verified email at ohsu.edu
Cited by 24451

Cellular and synaptic adaptations mediating opioid dependence

JT Williams, MDJ Christie… - Physiological …, 2001 - journals.physiology.org
Although opioids are highly effective for the treatment of pain, they are also known to be
intensely addictive. There has been a massive research investment in the development of opioid …

Nicotine activates and desensitizes midbrain dopamine neurons

VI Pidoplichko, M DeBiasi, JT Williams, JA Dani - Nature, 1997 - nature.com
Tobacco use in developed countries is estimated to be the single largest cause of premature
death 1 . Nicotine is the primary component of tobacco that drives use, and like other …

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

…, A Nimmerjahn, V Gradinaru, JT Williams… - Science, 2018 - science.org
INTRODUCTION Neuromodulators, such as dopamine, norepinephrine, or serotonin, exert
powerful control over neural circuit dynamics that give rise to diverse neural function and …

Regulation of µ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance

JT Williams, SL Ingram, G Henderson, C Chavkin… - Pharmacological …, 2013 - ASPET
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …

Local enforcement and better forests

CC Gibson, JT Williams, E Ostrom - World development, 2005 - Elsevier
Current studies of local resource management examine many factors thought to be associated
with good resource conditions. Despite the number of studies and the importance of such …

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

RA North, JT Williams, A Surprenant… - Proceedings of the …, 1987 - National Acad Sciences
The effects of agonists at mu and delta opioid receptors were compared by measuring
membrane currents under voltage clamp from neurons of the rat nucleus locus coeruleus and …

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

…, C Saez, M Mortrud, C Bouvier, JT Williams… - FEBS …, 1994 - Wiley Online Library
A novel G protein‐coupled receptor was cloned by PCR and homology screening. Its deduced
amino acid sequence is 47% identical overall to the μ, δ and κ opioid receptors and 64% …

Cells isolated from adult human skeletal muscle capable of differentiating into multiple mesodermal phenotypes

JT Williams IV, SS Southerland, J Souza… - The American …, 1999 - journals.sagepub.com
Wound healing is the response of tissue to injury that results in scar formation. Tissue
regeneration would be a more ideal response. Previously, we have isolated a population of cells …

Functional coupling between neurons and glia

…, F García-Hernández, JT Williams… - Journal of …, 2000 - Soc Neuroscience
Neuronal–glial interactions play an important role in information processing in the CNS.
Previous studies have indicated that electrotonic coupling between locus ceruleus (LC) neurons …

[BOOK][B] Multiple time series models

PT Brandt, JT Williams - 2007 - books.google.com
Many analyses of time series data involve multiple, related variables. Modeling Multiple Time
Series presents many specification choices and special challenges. This book reviews the …