Cholestasis, or impaired bile flow, is an important but poorly understood manifestation of liver
disease. Two clinically distinct forms of inherited cholestasis, benign recurrent intrahepatic …

Background High density genetic maps of plants have, nearly without exception, made use
of marker datasets containing missing or questionable genotype calls derived from a variety …

Objectives There is increasing evidence that polymorphism of the ABCB1 (MDR1) gene
contributes to interindividual variability in bioavailability and tissue distribution of P-glycoprotein …

The organic cation transporter, OCT1, is a major hepatic transporter that mediates the
uptake of many organic cations from the blood into the liver where the compounds may be …

Progressive familial intrahepatic cholestasis (PFIC) and benign recurrent intrahepatic
cholestasis (BRIC) are clinically distinct hereditary disorders. PFIC patients suffer from chronic …

Membrane transporters maintain cellular and organismal homeostasis by importing nutrients
and exporting toxic compounds. Transporters also play a crucial role in drug response, …

The completion of the Human Genome Project and the development of high-throughput
polymorphism identification methods have allowed researchers to carry out full genetic analyses …

Background Amyotrophic Lateral Sclerosis (ALS) is a lethal disorder characterized by
progressive degeneration of motor neurons in the brain and spinal cord. Diagnosis is mainly …

The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for
selecting markers for association studies, but it varies between populations. We assayed LD in …

We performed a genomewide search for linkage in an extended Dutch family with hereditary
vascular retinopathy associated with migraine and Raynaud phenomenon. Patients with …