[HTML][HTML] Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man

…, TC Williams, DB Lubahn, KS Korach - … England Journal of …, 1994 - Mass Medical Soc
Background and Methods Mutations in the estrogen-receptor gene have been thought to be
lethal. A 28-year-old man whose estrogen resistance was caused by a disruptive mutation in …

Estrogen receptor null mice: what have we learned and where will they lead us?

JF Couse, KS Korach - Endocrine reviews, 1999 - academic.oup.com
Elwood Jensen and Jack Gorski had spent 10 yr providing experimental evidence to support
the concept of an intracellular “receptor” protein for steroid hormones. Their combined work …

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

…, TS Golding, JF Couse, KS Korach… - Proceedings of the …, 1993 - National Acad Sciences
Estrogen receptor and its ligand, estradiol, have long been thought to be essential for survival,
fertility, and female sexual differentiation and development. Consistent with this proposed …

Generation and reproductive phenotypes of mice lacking estrogen receptor β

…, JF Mahler, M Sar, KS Korach… - Proceedings of the …, 1998 - National Acad Sciences
Estrogens influence the differentiation and maintenance of reproductive tissues and affect
lipid metabolism and bone remodeling. Two estrogen receptors (ERs) have been identified to …

[HTML][HTML] Estrogen receptors and human disease

BJ Deroo, KS Korach - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
Estrogens influence many physiological processes in mammals, including but not limited to
reproduction, cardiovascular health, bone integrity, cognition, and behavior. Given this …

[HTML][HTML] The multifaceted mechanisms of estradiol and estrogen receptor signaling

JM Hall, JF Couse, KS Korach - Journal of biological chemistry, 2001 - ASBMB
The steroid hormone 17ß-estradiol (E2) is a key regulator of growth, differentiation, and
function in a wide array of target tissues, including the male and female reproductive tracts, …

[HTML][HTML] Effect of testosterone and estradiol in a man with aromatase deficiency

…, S Serpente, J Boyd, KS Korach… - … England Journal of …, 1997 - Mass Medical Soc
Recent reports of disruptive mutations of the genes for the estrogen receptor or for cytochrome
P-450 aromatase 1 – 6 have shed new light on the role of estrogen. In females the lack of …

Tissue distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) messenger ribonucleic acid in the wild-type and ERα …

…, KAJ Grandien, JA Gustafsson, KS Korach - …, 1997 - academic.oup.com
Until recently, only a single type of estrogen receptor (ER) was thought to exist and mediate
the genomic effects of the hormone 17β-estradiol in mammalian tissues. However, the …

A role for oestrogens in the male reproductive system

…, D Bunick, KH Lee, J Bahr, JA Taylor, KS Korach… - Nature, 1997 - nature.com
Oestrogen is considered to be the ‘female’ hormone, whereas testosterone is considered
the ‘male’ hormone. However, both hormones are present in both sexes. Thus sexual …

International union of pharmacology. LXIV. Estrogen receptors

…, VC Jordan, JA Katzenellenbogen, KS Korach… - Pharmacological …, 2006 - ASPET
Estrogen receptors (ERs1) are ligand-activated transcription factors that belong to the nuclear
hormone receptor superfamily. In the late 1950s, the existence of a receptor molecule that …