Immunosuppressant drugs such as cyclosporin have allowed widespread organ
transplantation, but their utility remains limited by toxicities, and they are ineffective in chronic …

The cysteinyl leukotrienes—leukotriene C 4 (LTC 4 ), leukotriene D 4 (LTD 4 ) and
leukotriene E 4 (LTE 4 )—are important mediators of human bronchial asthma 1 , 2 , 3 ,. …

The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC 4 , LTD
4 , and LTE 4 , are thought to be mediated through at least two distinct but related CysLT G …

Proinflammatory cytokines have been shown to impair cognition; consequently, immune
activity in the central nervous system was considered detrimental to cognitive function. …

The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P),
are now recognized as important extracellular signaling molecules. These lipid mediators are …

The G protein-coupled receptor (GPCR) family share a structural motif of seven transmembrane
segments with large numbers of conserved residues in those regions. Here, we report …

We report the discovery, tissue distribution and pharmacological characterization of a novel
receptor, which we have named H4. Like the three histamine receptors reported previously (…

Sphingosine 1-phosphate (S1P), a multifunctional lipid mediator, regulates lymphocyte
trafficking, vascular permeability, and angiogenesis by activation of the S1P 1 receptor. This …

Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was
isolated first from porcine spinal cord and later from other species 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 . It is …

We report here the molecular cloning, tissue distribution, and chromosomal localization of
novel genes encoding G-protein-coupled receptors (GPCRs). A search of a mouse database …