Immunocyte Ca2+ Influx System Mediated by LTRPC2

…, S Mochizuki, H Yokoi, H Matsushime, K Furuichi - Science, 2001 - science.org
We characterized an activation mechanism of the human LTRPC2 protein, a member of the
transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates …

Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor

…, Y Ueda, H Matsushime, M Kobori, K Furuichi - Biochemical and …, 2005 - Elsevier
A lysophospholipid series, such as lysophosphatidic acid, lysophosphatidylserine, and
lysophosphatidylcholine (LPC), is a bioactive lipid mediator with diverse physiological and …

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

…, M Covarriubias, GV Desir, K Furuichi… - Pharmacological …, 2003 - ASPET
This summary article presents an overview of the molecular relationships among the voltage-gated
potassium channels and a standard nomenclature for them, which is derived from the …

Molecular identification of nicotinic acid receptor

…, H Hiyama, A Matsuo, H Matsushime, K Furuichi - Biochemical and …, 2003 - Elsevier
Nicotinic acid and its derivative, Acipimox, have been widely used in the treatment of
hyperlipidemia. Pharmacological studies have demonstrated that they exert the beneficial effect …

[HTML][HTML] Manipulation of alternative splicing by a newly developed inhibitor of Clks

…, J Yomoda, MV Murray, H Kimura, K Furuichi… - Journal of Biological …, 2004 - ASBMB
The regulation of splice site usage provides a versatile mechanism for controlling gene
expression and for the generation of proteome diversity, playing an essential role in many …

Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2

…, M Katoh, H Matsushime, K Furuichi… - Proceedings of the …, 2006 - National Acad Sciences
Prokineticins, multifunctional secreted proteins, activate two endogenous G protein-coupled
receptors PKR1 and PKR2. From in situ analysis of the mouse brain, we discovered that …

Molecular cloning and characterization of prokineticin receptors

…, T Ohishi, H Matsushime, K Furuichi - … et Biophysica Acta (BBA …, 2002 - Elsevier
Recent studies have identified two novel biofunctional proteins, termed prokineticin 1/EG-VEGF
and prokineticin 2, which were mammalian homologues of mamba MIT1 and frog Bv8. …

The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor

…, T Isogai, Y Suzuki, S Sugano, K Furuichi - Biochemical and …, 2000 - Elsevier
Cysteinyl leukotrienes (CysLTs), slow-reacting substances of anaphylaxis, are lipid mediators
known to possess potent proinflammatory action. Pharmacological studies using CysLTs …

[HTML][HTML] A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord

…, K Nozawa, H Okada, H Matsushime, K Furuichi - Journal of Biological …, 2003 - ASBMB
To find a novel human ion channel gene we have executed an extensive search by using a
human genome draft sequencing data base. Here we report a novel two-pore domain K + …

[HTML][HTML] Homodimer of two F-box proteins βTrCP1 or βTrCP2 binds to IκBα for signal-dependent ubiquitination

…, T Fujita, T Ikenoue, M Omata, K Furuichi… - Journal of Biological …, 2000 - ASBMB
We found previously that overexpression of an F-box protein βTrCP1 and the structurally
related βTrCP2 augments ubiquitination of phosphorylated IκBα (pIκBα) induced by tumor …