User profiles for Laura M. Bohn
Laura M. Bohn, PhDThe Herbert Wertheim UF Scripps Biomedical Institute for Technology & Innovation Verified email at ufl.edu Cited by 14502 |
Enhanced morphine analgesia in mice lacking β-arrestin 2
The ability of morphine to alleviate pain is mediated through a heterotrimeric guanine
nucleotide binding protein (G protein)–coupled heptahelical receptor (GPCR), the μ opioid …
nucleotide binding protein (G protein)–coupled heptahelical receptor (GPCR), the μ opioid …
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
Morphine is a powerful pain reliever, but also a potent inducer of tolerance and dependence.
The development of opiate tolerance occurs on continued use of the drug such that the …
The development of opiate tolerance occurs on continued use of the drug such that the …
Desensitization of G protein–coupled receptors and neuronal functions
▪ Abstract G protein–coupled receptors (GPCRs) have proven to be the most highly favorable
class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs are …
class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs are …
Morphine side effects in β-arrestin 2 knockout mice
KM Raehal, JKL Walker, LM Bohn - Journal of Pharmacology and …, 2005 - ASPET
Morphine is a potent analgesic, yet, like most opioid narcotics, it exerts unwanted side
effects such as constipation and respiratory suppression, thereby limiting its clinical utility. …
effects such as constipation and respiratory suppression, thereby limiting its clinical utility. …
[HTML][HTML] Crystal structure of the human cannabinoid receptor CB1
Cannabinoid receptor 1 (CB 1 ) is the principal target of Δ 9 -tetrahydrocannabinol (THC), a
psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications …
psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications …
[PDF][PDF] Bias factor and therapeutic window correlate to predict safer opioid analgesics
Biased agonism has been proposed as a means to separate desirable and adverse drug
responses downstream of G protein-coupled receptor (GPCR) targets. Herein, we describe …
responses downstream of G protein-coupled receptor (GPCR) targets. Herein, we describe …
Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
The action of norepinephrine (NE) is terminated, in part, by its uptake into presynaptic
noradrenergic neurons by the plasma-membrane NE transporter (NET), which is a target for …
noradrenergic neurons by the plasma-membrane NE transporter (NET), which is a target for …
Crystal structures of agonist-bound human cannabinoid receptor CB1
The cannabinoid receptor 1 (CB 1 ) is the principal target of the psychoactive constituent of
marijuana, the partial agonist Δ 9 -tetrahydrocannabinol (Δ 9 -THC) 1 . Here we report two …
marijuana, the partial agonist Δ 9 -tetrahydrocannabinol (Δ 9 -THC) 1 . Here we report two …
Differential mechanisms of morphine antinociceptive tolerance revealed in βarrestin-2 knock-out mice
Morphine induces antinociception by activating μ opioid receptors (μORs) in spinal and
supraspinal regions of the CNS. βarrestin-2 (βarr2), a G-protein-coupled receptor-regulating …
supraspinal regions of the CNS. βarrestin-2 (βarr2), a G-protein-coupled receptor-regulating …
[PDF][PDF] Crystal structure of the human cannabinoid receptor CB2
The cannabinoid receptor CB2 is predominately expressed in the immune system, and
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …