User profiles for Laura M. Bohn

Laura M. Bohn, PhD

The Herbert Wertheim UF Scripps Biomedical Institute for Technology & Innovation
Verified email at ufl.edu
Cited by 14502

Enhanced morphine analgesia in mice lacking β-arrestin 2

LM Bohn, RJ Lefkowitz, RR Gainetdinov, K Peppel… - Science, 1999 - science.org
The ability of morphine to alleviate pain is mediated through a heterotrimeric guanine
nucleotide binding protein (G protein)–coupled heptahelical receptor (GPCR), the μ opioid …

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

LM Bohn, RR Gainetdinov, FT Lin, RJ Lefkowitz… - Nature, 2000 - nature.com
Morphine is a powerful pain reliever, but also a potent inducer of tolerance and dependence.
The development of opiate tolerance occurs on continued use of the drug such that the …

Desensitization of G protein–coupled receptors and neuronal functions

RR Gainetdinov, RT Premont, LM Bohn… - Annu. Rev …, 2004 - annualreviews.org
▪ Abstract G protein–coupled receptors (GPCRs) have proven to be the most highly favorable
class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs are …

Morphine side effects in β-arrestin 2 knockout mice

KM Raehal, JKL Walker, LM Bohn - Journal of Pharmacology and …, 2005 - ASPET
Morphine is a potent analgesic, yet, like most opioid narcotics, it exerts unwanted side
effects such as constipation and respiratory suppression, thereby limiting its clinical utility. …

[HTML][HTML] Crystal structure of the human cannabinoid receptor CB1

…, I Kufareva, B Wu, Q Zhao, MA Hanson, LM Bohn… - Cell, 2016 - cell.com
Cannabinoid receptor 1 (CB 1 ) is the principal target of Δ 9 -tetrahydrocannabinol (THC), a
psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications …

[PDF][PDF] Bias factor and therapeutic window correlate to predict safer opioid analgesics

…, J Morgenweck, MD Cameron, TD Bannister, LM Bohn - Cell, 2017 - cell.com
Biased agonism has been proposed as a means to separate desirable and adverse drug
responses downstream of G protein-coupled receptor (GPCR) targets. Herein, we describe …

Mice lacking the norepinephrine transporter are supersensitive to psychostimulants

…, RR Gainetdinov, WC Wetsel, SR Jones, LM Bohn… - Nature …, 2000 - nature.com
The action of norepinephrine (NE) is terminated, in part, by its uptake into presynaptic
noradrenergic neurons by the plasma-membrane NE transporter (NET), which is a target for …

Crystal structures of agonist-bound human cannabinoid receptor CB1

…, K Ding, X Li, H Liu, MA Hanson, S Zhao, LM Bohn… - Nature, 2017 - nature.com
The cannabinoid receptor 1 (CB 1 ) is the principal target of the psychoactive constituent of
marijuana, the partial agonist Δ 9 -tetrahydrocannabinol (Δ 9 -THC) 1 . Here we report two …

Differential mechanisms of morphine antinociceptive tolerance revealed in βarrestin-2 knock-out mice

LM Bohn, RJ Lefkowitz, MG Caron - Journal of Neuroscience, 2002 - Soc Neuroscience
Morphine induces antinociception by activating μ opioid receptors (μORs) in spinal and
supraspinal regions of the CNS. βarrestin-2 (βarr2), a G-protein-coupled receptor-regulating …

[PDF][PDF] Crystal structure of the human cannabinoid receptor CB2

…, J Wang, M Wu, V Katritch, S Zhao, G Kunos, LM Bohn… - Cell, 2019 - cell.com
The cannabinoid receptor CB2 is predominately expressed in the immune system, and
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …