User profiles for Laurence J. Miller
Laurence J. MillerMayo Clinic Verified email at mayo.edu Cited by 25041 |
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery
T Kenakin, LJ Miller - Pharmacological reviews, 2010 - ASPET
It is useful to consider seven transmembrane receptors (7TMRs) as disordered proteins able
to allosterically respond to a number of binding partners. Considering 7TMRs as allosteric …
to allosterically respond to a number of binding partners. Considering 7TMRs as allosteric …
Single-molecule FRET imaging of GPCR dimers in living cells
Class CG protein-coupled receptors (GPCRs) are known to form stable homodimers or
heterodimers critical for function, but the oligomeric status of class A and B receptors, which …
heterodimers critical for function, but the oligomeric status of class A and B receptors, which …
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases,
such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length …
such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length …
The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …
Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas
Background & Aims: The aim of this study was to determine recurrence and long-term survival
after resection of pancreatic intraductal papillary mucinous neoplasm and to correlate …
after resection of pancreatic intraductal papillary mucinous neoplasm and to correlate …
[PDF][PDF] The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism
Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise
of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding …
of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding …
International Union of Pharmacology. XXXV. The glucagon receptor family
Peptide hormones within the secretin-glucagon family are expressed in endocrine cells of
the pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and …
the pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and …
Expression cloning and characterization of the canine parietal cell gastrin receptor.
…, YM Lee, EW McBride, LJ Miller… - Proceedings of the …, 1992 - National Acad Sciences
Gastrin is an important stimulant of acid secretion by gastric parietal cells and is structurally
related to the peptide hormone cholecystokinin (CCK). The pharmacologic properties of the …
related to the peptide hormone cholecystokinin (CCK). The pharmacologic properties of the …
Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled receptor
(GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three major …
(GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three major …
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
The class B glucagon-like peptide-1 (GLP-1) G protein-coupled receptor is a major target for
the treatment of type 2 diabetes and obesity 1 . Endogenous and mimetic GLP-1 peptides …
the treatment of type 2 diabetes and obesity 1 . Endogenous and mimetic GLP-1 peptides …