User profiles for Laurence J. Miller

Laurence J. Miller

Mayo Clinic
Verified email at mayo.edu
Cited by 25041

Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

T Kenakin, LJ Miller - Pharmacological reviews, 2010 - ASPET
It is useful to consider seven transmembrane receptors (7TMRs) as disordered proteins able
to allosterically respond to a number of binding partners. Considering 7TMRs as allosteric …

Single-molecule FRET imaging of GPCR dimers in living cells

…, Z Zhou, KG Harikumar, K Jaqaman, LJ Miller… - Nature …, 2021 - nature.com
Class CG protein-coupled receptors (GPCRs) are known to form stable homodimers or
heterodimers critical for function, but the oligomeric status of class A and B receptors, which …

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

…, T Coudrat, R Danev, W Baumeister, LJ Miller… - Nature, 2017 - nature.com
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases,
such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length …

The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors

…, S Melmed, MC Michel, LJ Miller… - British journal of …, 2021 - Wiley Online Library
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas

ST Chari, D Yadav, TC Smyrk, EP DiMagno, LJ Miller… - Gastroenterology, 2002 - Elsevier
Background & Aims: The aim of this study was to determine recurrence and long-term survival
after resection of pancreatic intraductal papillary mucinous neoplasm and to correlate …

[PDF][PDF] The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism

…, SGB Furness, M Liu, PE Thompson, LJ Miller… - Cell, 2016 - cell.com
Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise
of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding …

International Union of Pharmacology. XXXV. The glucagon receptor family

KE Mayo, LJ Miller, D Bataille, S Dalle, B Göke… - Pharmacological …, 2003 - ASPET
Peptide hormones within the secretin-glucagon family are expressed in endocrine cells of
the pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and …

Expression cloning and characterization of the canine parietal cell gastrin receptor.

…, YM Lee, EW McBride, LJ Miller… - Proceedings of the …, 1992 - National Acad Sciences
Gastrin is an important stimulant of acid secretion by gastric parietal cells and is structurally
related to the peptide hormone cholecystokinin (CCK). The pharmacologic properties of the …

Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes

…, J Lau, PM Sexton, LJ Miller, JM Ahn, J Liao… - Pharmacological …, 2016 - ASPET
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled receptor
(GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three major …

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

…, R Danev, W Baumeister, MW Wang, LJ Miller… - Nature, 2018 - nature.com
The class B glucagon-like peptide-1 (GLP-1) G protein-coupled receptor is a major target for
the treatment of type 2 diabetes and obesity 1 . Endogenous and mimetic GLP-1 peptides …