User profiles for Luke A.J. O'Neill
 | Luke O'NeillTrinity College Dublin Verified email at tcd.ie Cited by 101281 |
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
LAJ O'Neill, AG Bowie - Nature Reviews Immunology, 2007 - nature.com
Signalling by Toll-like receptors (TLRs) involves five adaptor proteins known as MyD88,
MAL, TRIF, TRAM and SARM. Recent insights have revealed additional functions for MyD88 …
MAL, TRIF, TRAM and SARM. Recent insights have revealed additional functions for MyD88 …
A guide to immunometabolism for immunologists
LAJ O'Neill, RJ Kishton, J Rathmell - Nature reviews immunology, 2016 - nature.com
In recent years a substantial number of findings have been made in the area of immunometabolism,
by which we mean the changes in intracellular metabolic pathways in immune cells …
by which we mean the changes in intracellular metabolic pathways in immune cells …
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
The NOD-like receptor (NLR) family, pyrin domain–containing protein 3 (NLRP3) inflammasome
is a component of the inflammatory process, and its aberrant activation is pathogenic in …
is a component of the inflammatory process, and its aberrant activation is pathogenic in …
The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress
LAJ O'Neill - Immunological reviews, 2008 - Wiley Online Library
The interleukin‐1 receptor (IL‐1R)/Toll‐like receptor (TLR) superfamily was first defined in
1998 as a family of proteins that contain the Toll‐IL‐1 receptor domain. At that time, there were …
1998 as a family of proteins that contain the Toll‐IL‐1 receptor domain. At that time, there were …
Trained immunity: a program of innate immune memory in health and disease
BACKGROUND Host immune responses are classically divided into innate immune responses,
which react rapidly and nonspecifically upon encountering a pathogen, and adaptive …
which react rapidly and nonspecifically upon encountering a pathogen, and adaptive …
The history of Toll-like receptors—redefining innate immunity
The discovery of Toll-like receptors (TLRs) was an important event for immunology research
and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or …
and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or …
Negative regulation of toll-like receptor-mediated immune responses
Toll-like receptors (TLRs) are involved in host defence against invading pathogens, functioning
as primary sensors of microbial products and activating signalling pathways that induce …
as primary sensors of microbial products and activating signalling pathways that induce …
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
…, D McMurray, DE Smith, JE Sims, TA Bird, LAJ O'Neill - Nature, 2001 - nature.com
The recognition of microbial pathogens by the innate immune system involves Toll-like
receptors (TLRs), which recognize pathogen-associated molecular patterns 1 , 2 , 3 , 4 , 5 , 6 , 7 , …
receptors (TLRs), which recognize pathogen-associated molecular patterns 1 , 2 , 3 , 4 , 5 , 6 , 7 , …
Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4
EM Pålsson‐McDermott, LAJ O'Neill - Immunology, 2004 - Wiley Online Library
An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort
to provide a molecular basis for the lethal effect of LPS during septic shock and point the way …
to provide a molecular basis for the lethal effect of LPS during septic shock and point the way …
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show
that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in …
that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in …