User profiles for M. J. Cairns

Murray Cairns

University of Newcastle
Verified email at newcastle.edu.au
Cited by 25421

Identifying miRNAs, targets and functions

B Liu, J Li, MJ Cairns - Briefings in bioinformatics, 2014 - academic.oup.com
microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the universal
specificity factors in post-transcriptional gene silencing. Discovering miRNAs, identifying …

Advancing the use of genome-wide association studies for drug repurposing

WR Reay, MJ Cairns - Nature Reviews Genetics, 2021 - nature.com
Genome-wide association studies (GWAS) have revealed important biological insights into
complex diseases, which are broadly expected to lead to the identification of new drug …

[HTML][HTML] MicroRNA dysregulation in schizophrenia

NJ Beveridge, MJ Cairns - Neurobiology of disease, 2012 - Elsevier
Schizophrenia is a complex neuropsychiatric disorder that involves disturbances in neural
circuitry and synaptic function. The exquisite network architecture and capacity for discreet …

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

…, RL Buckner, J Bybjerg-Grauholm, W Cahn, MJ Cairns… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

…, W Byerley, W Cahn, G Cai, MJ Cairns… - Nature …, 2017 - nature.com
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …

[HTML][HTML] Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta …

…, C Pantelis, Y Quidé, U Schall, RJ Scott, MJ Cairns… - Biological …, 2018 - Elsevier
Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …

[PDF][PDF] Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes

…, W Byerley, W Cahn, G Cai, MJ Cairns… - Cell, 2018 - cell.com
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

[HTML][HTML] Schizophrenia is associated with an increase in cortical microRNA biogenesis

…, E Gardiner, AP Carroll, PA Tooney, MJ Cairns - Molecular …, 2010 - nature.com
MicroRNA expression profiling and quantitative reverse transcription-PCR analysis of the
superior temporal gyrus and the dorsolateral prefrontal cortex revealed a significant …

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

…, S Nakagawa, F Rigo, RJ Taft, MJ Cairns… - Molecular …, 2014 - nature.com
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia

…, J Weidenhofer, M Hinwood, MJ Cairns… - Brain, behavior, and …, 2012 - Elsevier
Selective serotonin and serotonin norepinephrine reuptake inhibitors (SSRI; SNRI) are the
first choice pharmacological treatment options for major depression. It has long been …