The metabolism in vivo of several volatile anesthetics has been determined in the rat. The
anesthetics studied were ether, chloroform, methoxyflurane, and halothane, all of which have …

The inhalation toxicity of ethylene oxide cyclic tetramer vapor (EOCT), a synthetic compound,
has been evaluated. Rats were exposed to 0.5 and 1.0 ppm ethylene oxide cyclic tetramer …

Determinations were made of ethanol preference and behavioral tolerance in 4 experiments
with inbred strains of mice. High-and low-preference strains were compared on neural …

Halogenation modifies the pharmacological properties and uses of a host of compounds.
This is accomplished at the molecular level by different mechanisms, several of which are …

The in vitro metabolism of halothane and methoxyflurane has been investigated. With either
chlorine-36 or carbon-14-labeled material, it has been found that the chlorine is …

1. The ability of various chemical substances to prevent or reverse the toxic effects of
sodium fluoroacetate has been studied in mice, rats, rabbits, dogs and rhesus monkeys (Macacca …

To summarize the current position of metal‐chelating drugs in medicine is not difficult.
Arsenic and mercury poisonings call for immediate systematic treatment with dimercaprol; …

1. Spike and dome waves of high voltage occurring at a 3 per second rate have been produced
in the EEG of curarized dogs by the administration of fluoroacetic acid. 2. Six of 8 dogs …

METHOD Under ether anesthesia a cat’s heart was removed and an incision made along
the border of the right ventricle. Suitable papillary muscles3 were removed with the chordae …

The injection of either fluoroacetate or fluorobutyrate into a piece of isolated dog cerebral
cortex produces localized convulsive seizures and citrate accumulation, indicating that the …