The nucleotide adenosine 5′-triphosphate (ATP) has classically been considered the cell's
primary energy currency. Importantly, a novel role for ATP as an extracellular autocrine and/…

Abstract Models of unregulated nitric oxide (NO) diffusion do not consistently account for the
biochemistry of NO synthase (NOS)-dependent signalling in many cell systems 1 , 2 , 3 . For …

Rationale: The coordination of vascular smooth muscle cell constriction plays an important
role in vascular function, such as regulation of blood pressure; however, the mechanism …

Objective— To determine whether S-nitrosylation of connexins (Cxs) modulates gap
junction communication between endothelium and smooth muscle. Methods and Results— …

Both purinergic signaling through nucleotides such as ATP (adenosine 5′-triphosphate)
and noradrenergic signaling through molecules such as norepinephrine regulate vascular …

S-Nitrosylation is a post-translational modification on cysteine(s) that can regulate protein
function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric …

It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …

Posttranslational modification is a common cellular process that is used by cells to ensure a
particular protein function. This can happen in a variety of ways, eg, from the addition of …

Aims: Pannexins (Panx) form ATP release channels and it has been proposed that they play
an important role in the regulation of vascular tone. However, distribution of Panx across the …

Extracellular matrix (ECM)-derived bioscaffolds have been shown to elicit tissue repair through
retention of bioactive signals. Given that the adventitia of large blood vessels is a richly …