User profiles for Mark Kindy

Mark Kindy

Professor of Neurosciences, Medical University of South Carolina
Verified email at musc.edu
Cited by 20431

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

AJ Bruce, W Boling, MS Kindy, J Peschon… - Nature medicine, 1996 - nature.com
Brain injury, as occurs in stroke or head trauma, induces a dramatic increase in levels of
tumor necrosis factor–α (TNF), but its role in brain injury response is unknown. We generated …

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

…, B Liliensiek, P Nawroth, F Hofman, M Kindy… - Nature medicine, 2003 - nature.com
Amyloid-β peptide (Aβ) interacts with the vasculature to influence Aβ levels in the brain and
cerebral blood flow, providing a means of amplifying the Aβ-induced cellular stress …

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid …

JN Keller, MS Kindy, FW Holtsberg… - Journal of …, 1998 - Soc Neuroscience
Oxidative stress is implicated in neuronal apoptosis that occurs in physiological settings and
in neurodegenerative disorders. Superoxide anion radical, produced during mitochondrial …

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

Y Li, TA Perry, MS Kindy, BK Harvey… - Proceedings of the …, 2009 - National Acad Sciences
Glucagon-like peptide-1 (GLP-1) is an endogenous insulinotropic peptide secreted from the
gastrointestinal tract in response to food intake. It enhances pancreatic islet β-cell …

Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury

…, I Merchenthaler, MS Kindy… - Proceedings of the …, 2001 - National Acad Sciences
Estradiol protects against brain injury, neurodegeneration, and cognitive decline. Our previous
work demonstrates that physiological levels of estradiol protect against stroke injury and …

Inhibition of Alzheimer's amyloidosis by peptides that prevent β-sheet conformation

C Soto, MS Kindy, M Baumann, B Frangione - Biochemical and biophysical …, 1996 - Elsevier
Amyloid β-peptide (Aβ) is a major fibrillar component of neuritic plaques in Alzheimer's
disease (AD) brains and is related to the pathogenesis of the disease. We hypothesized that …

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice

…, E Rockenstein, A Mukherjee, MS Kindy… - Journal of …, 2003 - Soc Neuroscience
The degenerative process of Alzheimer's disease is linked to a shift in the balance between
amyloid-β (Aβ) production, clearance, and degradation. Neprilysin has recently been …

High cholesterol‐induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

…, K Sambamurti, MS Kindy… - Journal of …, 2008 - Wiley Online Library
Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer’s
disease‐like dementia but the underlying mechanisms remain unknown. In this study, we …

RAGE potentiates Aβ‐induced perturbation of neuronal function in transgenic mice

…, M Buttini, L Mucke, W Li, AM Schmidt, M Kindy… - The EMBO …, 2004 - embopress.org
Receptor for Advanced Glycation Endproducts (RAGE), a multiligand receptor in the
immunoglobulin superfamily, functions as a signal‐transducing cell surface acceptor for amyloid‐…

Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

…, J Yu, C Soto, AM Schmidt, D Stern, M Kindy - Nature medicine, 2000 - nature.com
Accumulation of fibrils composed of amyloid A in tissues resulting in displacement of normal
structures and cellular dysfunction is the characteristic feature of systemic amyloidoses. …