User profiles for Mark Kindy
Mark KindyProfessor of Neurosciences, Medical University of South Carolina Verified email at musc.edu Cited by 20431 |
Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
AJ Bruce, W Boling, MS Kindy, J Peschon… - Nature medicine, 1996 - nature.com
Brain injury, as occurs in stroke or head trauma, induces a dramatic increase in levels of
tumor necrosis factor–α (TNF), but its role in brain injury response is unknown. We generated …
tumor necrosis factor–α (TNF), but its role in brain injury response is unknown. We generated …
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
…, B Liliensiek, P Nawroth, F Hofman, M Kindy… - Nature medicine, 2003 - nature.com
Amyloid-β peptide (Aβ) interacts with the vasculature to influence Aβ levels in the brain and
cerebral blood flow, providing a means of amplifying the Aβ-induced cellular stress …
cerebral blood flow, providing a means of amplifying the Aβ-induced cellular stress …
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid …
JN Keller, MS Kindy, FW Holtsberg… - Journal of …, 1998 - Soc Neuroscience
Oxidative stress is implicated in neuronal apoptosis that occurs in physiological settings and
in neurodegenerative disorders. Superoxide anion radical, produced during mitochondrial …
in neurodegenerative disorders. Superoxide anion radical, produced during mitochondrial …
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
Glucagon-like peptide-1 (GLP-1) is an endogenous insulinotropic peptide secreted from the
gastrointestinal tract in response to food intake. It enhances pancreatic islet β-cell …
gastrointestinal tract in response to food intake. It enhances pancreatic islet β-cell …
Estrogen receptor α, not β, is a critical link in estradiol-mediated protection against brain injury
…, I Merchenthaler, MS Kindy… - Proceedings of the …, 2001 - National Acad Sciences
Estradiol protects against brain injury, neurodegeneration, and cognitive decline. Our previous
work demonstrates that physiological levels of estradiol protect against stroke injury and …
work demonstrates that physiological levels of estradiol protect against stroke injury and …
Inhibition of Alzheimer's amyloidosis by peptides that prevent β-sheet conformation
Amyloid β-peptide (Aβ) is a major fibrillar component of neuritic plaques in Alzheimer's
disease (AD) brains and is related to the pathogenesis of the disease. We hypothesized that …
disease (AD) brains and is related to the pathogenesis of the disease. We hypothesized that …
Neprilysin gene transfer reduces human amyloid pathology in transgenic mice
…, E Rockenstein, A Mukherjee, MS Kindy… - Journal of …, 2003 - Soc Neuroscience
The degenerative process of Alzheimer's disease is linked to a shift in the balance between
amyloid-β (Aβ) production, clearance, and degradation. Neprilysin has recently been …
amyloid-β (Aβ) production, clearance, and degradation. Neprilysin has recently been …
High cholesterol‐induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
…, K Sambamurti, MS Kindy… - Journal of …, 2008 - Wiley Online Library
Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer’s
disease‐like dementia but the underlying mechanisms remain unknown. In this study, we …
disease‐like dementia but the underlying mechanisms remain unknown. In this study, we …
RAGE potentiates Aβ‐induced perturbation of neuronal function in transgenic mice
Receptor for Advanced Glycation Endproducts (RAGE), a multiligand receptor in the
immunoglobulin superfamily, functions as a signal‐transducing cell surface acceptor for amyloid‐…
immunoglobulin superfamily, functions as a signal‐transducing cell surface acceptor for amyloid‐…
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
Accumulation of fibrils composed of amyloid A in tissues resulting in displacement of normal
structures and cellular dysfunction is the characteristic feature of systemic amyloidoses. …
structures and cellular dysfunction is the characteristic feature of systemic amyloidoses. …