User profiles for Maurizio Bifulco

Maurizio Bifulco

University of Salerno
Verified email at unisa.it
Cited by 15577

The endocannabinoid system and its therapeutic exploitation

VD Marzo, M Bifulco, LD Petrocellis - Nature reviews Drug discovery, 2004 - nature.com
The term 'endocannabinoid' — originally coined in the mid-1990s after the discovery of
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol and …

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

…, L De Petrocellis, C Laezza, G Portella, M Bifulco… - … of Pharmacology and …, 2006 - ASPET
Δ 9 -Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but
its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor …

Cannabidiol: State of the art and new challenges for therapeutic applications

…, MC Proto, D Fiore, C Laezza, M Bifulco - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9 -THC and cannabidiol (CBD) are the most …

Pharmacological actions of statins: a critical appraisal in the management of cancer

…, S Pisanti, A Santoro, C Laezza, M Bifulco - Pharmacological …, 2012 - ASPET
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently, a …

The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation

…, T Bisogno, C Laezza, M Bifulco… - Proceedings of the …, 1998 - National Acad Sciences
Anandamide was the first brain metabolite shown to act as a ligand of “central” CB1 cannabinoid
receptors. Here we report that the endogenous cannabinoid potently and selectively …

[HTML][HTML] Role of the small GTPase Rab7 in the late endocytic pathway

…, M Santillo, D Lattero, M Chiariello, M Bifulco… - Journal of Biological …, 1997 - ASBMB
Rab7 is a small GTPase localized to the late endosomal compartment. Its function was
investigated by overexpressing dominant negative or constitutively active mutants in BHK-21 cells…

Possible endocannabinoid control of colorectal cancer growth

…, V Cosenza, G D'argenio, G Scaglione, M Bifulco… - Gastroenterology, 2003 - Elsevier
Background & Aims : The endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG)
inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied (1) …

[HTML][HTML] Cannabinoids: therapeutic use in clinical practice

…, G Navarra, L Coppola, G Avilia, M Bifulco… - International journal of …, 2022 - mdpi.com
Medical case reports suggest that cannabinoids extracted from Cannabis sativa have therapeutic
effects; however, the therapeutic employment is limited due to the psychotropic effect of …

Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell …

…, P Orlando, T Bisogno, C Laezza, M Bifulco… - …, 2000 - academic.oup.com
Anandamide and 2-arachidonoylglycerol (2-AG), two endogenous ligands of the CB1 and
CB2 cannabinoid receptor subtypes, inhibit the proliferation of PRL-responsive human breast …

[HTML][HTML] Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism

…, S Zappavigna, M Marra, A Abbruzzese, M Bifulco… - Cell death & …, 2011 - nature.com
Gemcitabine (GEM, 2′, 2′-difluorodeoxycytidine) is currently used in advanced pancreatic
adenocarcinoma, with a response rate of< 20%. The purpose of our work was to improve …