User profiles for Maurizio Bifulco
Maurizio BifulcoUniversity of Salerno Verified email at unisa.it Cited by 15577 |
The endocannabinoid system and its therapeutic exploitation
The term 'endocannabinoid' — originally coined in the mid-1990s after the discovery of
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol and …
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol and …
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
…, L De Petrocellis, C Laezza, G Portella, M Bifulco… - … of Pharmacology and …, 2006 - ASPET
Δ 9 -Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but
its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor …
its use in chemotherapy is limited by its psychotropic activity. We investigated the antitumor …
Cannabidiol: State of the art and new challenges for therapeutic applications
…, MC Proto, D Fiore, C Laezza, M Bifulco - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9 -THC and cannabidiol (CBD) are the most …
derivatives and in particular phytocannabinoids. Δ 9 -THC and cannabidiol (CBD) are the most …
Pharmacological actions of statins: a critical appraisal in the management of cancer
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently, a …
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently, a …
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
Anandamide was the first brain metabolite shown to act as a ligand of “central” CB1 cannabinoid
receptors. Here we report that the endogenous cannabinoid potently and selectively …
receptors. Here we report that the endogenous cannabinoid potently and selectively …
[HTML][HTML] Role of the small GTPase Rab7 in the late endocytic pathway
Rab7 is a small GTPase localized to the late endosomal compartment. Its function was
investigated by overexpressing dominant negative or constitutively active mutants in BHK-21 cells…
investigated by overexpressing dominant negative or constitutively active mutants in BHK-21 cells…
Possible endocannabinoid control of colorectal cancer growth
…, V Cosenza, G D'argenio, G Scaglione, M Bifulco… - Gastroenterology, 2003 - Elsevier
Background & Aims : The endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG)
inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied (1) …
inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied (1) …
[HTML][HTML] Cannabinoids: therapeutic use in clinical practice
Medical case reports suggest that cannabinoids extracted from Cannabis sativa have therapeutic
effects; however, the therapeutic employment is limited due to the psychotropic effect of …
effects; however, the therapeutic employment is limited due to the psychotropic effect of …
Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell …
Anandamide and 2-arachidonoylglycerol (2-AG), two endogenous ligands of the CB1 and
CB2 cannabinoid receptor subtypes, inhibit the proliferation of PRL-responsive human breast …
CB2 cannabinoid receptor subtypes, inhibit the proliferation of PRL-responsive human breast …
[HTML][HTML] Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
…, S Zappavigna, M Marra, A Abbruzzese, M Bifulco… - Cell death & …, 2011 - nature.com
Gemcitabine (GEM, 2′, 2′-difluorodeoxycytidine) is currently used in advanced pancreatic
adenocarcinoma, with a response rate of< 20%. The purpose of our work was to improve …
adenocarcinoma, with a response rate of< 20%. The purpose of our work was to improve …