[HTML][HTML] Activation of the human androgen receptor through a protein kinase A signaling pathway

LV Nazareth, NL Weigel - Journal of Biological Chemistry, 1996 - ASBMB
Aberrant activation of the androgen receptor through signaling pathways independent of
androgen may be responsible for the progression of prostate tumors to the rapidly proliferating …

Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation

SY Tsai, J Carlstedt-Duke, NL Weigel, K Dahlman… - Cell, 1988 - cell.com
A steroid hormone responsive element (GREIPRE), sufficient to confer glucocorticold and
progesterone inducibility when linked to a reporter gene, was used in band-shift assays to …

Androgen receptor mutations in prostate cancer

…, E Puxeddu, A Esen, J Eastham, NL Weigel… - Cancer research, 2000 - AACR
We analyzed the frequency and relevance of mutations in the coding region of the androgen
receptor (AR) in genomic DNA extracted from 137 specimens of prostate cancer. The …

International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone …

…, RB Hochberg, L McKay, JM Renoir, NL Weigel… - Pharmacological …, 2006 - ASPET
The glucocorticoid receptor (GR1), mineralocorticoid receptor (MR), progesterone receptor (PR),
and androgen receptor (AR) are classic members of the nuclear receptor superfamily, …

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the …

…, GN DeMartino, M Marcelli, NL Weigel… - Human molecular …, 1999 - academic.oup.com
Spinal bulbar muscular atrophy is a neurodegenerative disorder caused by a polyglutamine
expansion in the androgen receptor (AR). We show in transiently transfected HeLa cells that …

Ligand-independent activation of steroid hormone receptors

NL Weigel, Y Zhang - Journal of molecular medicine, 1998 - Springer
In addition to the conventional hormone-dependent regulation of the activity of steroid/thyroid
receptor family members, many studies have shown that there is substantial cross-talk …

Androgen receptors in hormone-dependent and castration-resistant prostate cancer

AA Shafi, AE Yen, NL Weigel - Pharmacology & therapeutics, 2013 - Elsevier
In the United States, prostate cancer (PCa) is the most commonly diagnosed non-cutaneous
cancer in males and the second leading cause of cancer-related death for men. The …

Steroid hormone receptors and their regulation by phosphorylation

NL Weigel - Biochemical Journal, 1996 - portlandpress.com
The steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors
encompasses not only the receptors for steroids, thyroid hormone, retinoids and vitamin D, but …

[PDF][PDF] Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress

…, Y Zhang, BD Darimont, K Simpson, NL Weigel… - Molecular cell, 1999 - cell.com
Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor that serves as an essential
regulator of many hormone-induced genes in the vertebrate endocrine system. The apparent …

Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2

SE Blutt, TJ McDonnell, TC Polek, NL Weigel - Endocrinology, 2000 - academic.oup.com
While the role of vitamin D in bone and mineral metabolism has been investigated
extensively, the role of the vitamin D receptor in other tissues is less well understood. 1,25-…