Typically considered to be cell surface sensors of extracellular signals, heterotrimeric GTP-binding
protein (G protein)–coupled receptors (GPCRs) control many pathophysiological …

Serine proteases such as trypsin and mast cell tryptase cleave protease-activated receptor-2
(PAR 2 ) at R 36 ↓S 37 and reveal a tethered ligand that excites nociceptors, causing …

G protein-coupled receptors (GPCRs) are the major class of sensory proteins and a primary
therapeutic target in the pathways to pain and itch. GPCRs are complex signaling machines. …

Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …

G protein-coupled receptors of nociceptive neurons can sensitize transient receptor
potential (TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated …

G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma
membrane, where they interact with extracellular ligands and couple to G proteins that transmit …

Once activated at the surface of cells, G protein-coupled receptors (GPCRs) redistribute to
endosomes, where they can continue to signal. Whether GPCRs in endosomes generate …

… Author links open overlay panel Nicolas Cenac 1 2 3 , Tereza Bautzova 1 2 3 , Pauline
Le Faouder 1 2 3 4 5 , Nicholas A. Veldhuis 6 , Daniel P. Poole 6 7 , Corinne Rolland 1 2 3 , …

The neuropeptide substance P (SP) is important in pain and inflammation. SP activates the
neurokinin-1 receptor (NK1R) to signal via G q and G s proteins. Neurokinin A also activates …

Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because
of the endosomal transport mechanisms of many nanomedicines within cells. Here, we …