International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

…, EJ Mylecharane, PR Saxena, PP Humphrey - Pharmacological …, 1994 - ASPET
It is evident that in the last decade or so, a vast amount of new information has become
available concerning the various 5-HT receptor types and their characteristics. This derives from …

Serotonin and migraine.

PP Humphrey, W Feniuk, MJ Perren… - Annals of the new …, 1990 - europepmc.org
Migraine has long been considered as a" vascular headache" but clearly neurological
mechanisms are involved. The pathophysiology appears to somehow involve serotonin, both …

Telavancin, a Multifunctional Lipoglycopeptide, Disrupts both Cell Wall Synthesis and Cell Membrane Integrity in Methicillin-Resistant Staphylococcus aureus

…, DE Karr, BM Benton, PP Humphrey - Antimicrobial agents …, 2005 - Am Soc Microbiol
The emergence and spread of multidrug-resistant gram-positive bacteria represent a serious
clinical problem. Telavancin is a novel lipoglycopeptide antibiotic that possesses rapid in …

Telavancin disrupts the functional integrity of the bacterial membrane through targeted interaction with the cell wall precursor lipid II

…, JW Janc, M Mammen, PP Humphrey… - Antimicrobial agents …, 2009 - Am Soc Microbiol
Polypropylene laboratory ware was used for the preparation of stock solutions and the
subsequent dilution procedures. Nisin stock solutions were prepared in deionized water, which …

Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle …

RA Coleman, PP Humphrey, I Kennedy… - British journal of …, 1981 - ncbi.nlm.nih.gov
The actions of the prostaglandin H2 (PGH2) analogue, U-46619, have been compared with
those of PGH2 on thromboxane A2 (TxA2) on a range of isolated smooth muscle …

Pharmacological and anti-emetic properties of ondansetron.

MB Tyers, KT Bunce, PP Humphrey - European journal of cancer & …, 1989 - europepmc.org
Three main types of 5-HT (serotonin) receptor have been recognised. The 5-HT3 receptor is
located on neuronal tissues in the peripheral and central nervous systems. Ondansetron is …

GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein.

PP Humphrey, W Feniuk, MJ Perren… - British Journal of …, 1988 - ncbi.nlm.nih.gov
We describe the actions of a novel and selective 5-HT1-like receptor agonist, GR43175, in a
range of isolated tissue preparations containing different 5-hydroxytryptamine (5-HT) …

Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV …

…, SE Beachboard, PP Humphrey… - Clinical and vaccine …, 2007 - Am Soc Microbiol
We used a severe challenge model that produces clinical West Nile virus (WNV) disease to
test the efficacy of three commercially available equine WNV vaccines in horses. Twenty-four …

Electrophysiological properties of P2X‐purinoceptors in rat superior cervical, nodose and guinea‐pig coeliac neurones.

BS Khakh, PP Humphrey… - The Journal of …, 1995 - Wiley Online Library
1. Whole‐cell recordings were made from guinea‐pig coeliac, rat nodose and rat superior
cervical (SCG) neurones in culture, and currents in response to fast‐flow (concentration clamp…

Chloride secretion in response to guanylin in colonic epithelial from normal and transgenic cystic fibrosis mice.

…, R Ratcliff, PW Seale, PP Humphrey - British journal of …, 1994 - ncbi.nlm.nih.gov
Guanylin, a 15 amino acid endogenous gut peptide, increased the short circuit current (SCC)
in the epithelium of the mouse colon, but only when applied to the apical and not the …