User profiles for P Seeman
 | Philip Seemanpharmacology and psychiatry University of Toronto Verified email at utoronto.ca Cited by 61844 |
[PDF][PDF] The membrane actions of anesthetics and tranquilizers
P Seeman - Pharmacol rev, 1972 - researchgate.net
X. Anesthetic effects on solute translocation across membranes 630 XI. On which side of the
membrane do anesthetics act? 631 XII. Summary 632 let us remember that chloroform does …
membrane do anesthetics act? 631 XII. Summary 632 let us remember that chloroform does …
Does Fast Dissociation From the Dopamine D2 Receptor Explain the Action of Atypical Antipsychotics?: A New Hypothesis
… Kapur S, Zipursky R, Jones C, Shammi CS, Remington G, Seeman P: A positron emission
tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic …
tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic …
Dopamine receptor pharmacology
P Seeman, HHM Van Tol - Trends in pharmacological sciences, 1994 - cell.com
Brain dopamine receptors are the primary targets in the medical treatment of schizophret~
Parkinson's di~, a~ e H=~ aSto~'s chorea.~ ptor ant~,, or~(or neuroleptics) such as halope~ lol …
Parkinson's di~, a~ e H=~ aSto~'s chorea.~ ptor ant~,, or~(or neuroleptics) such as halope~ lol …
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
…, JR Bunzow, HC Guan, RK Sunahara, P Seeman… - Nature, 1991 - nature.com
… Male polymorphism in P sculpta provides such a … The library was hybridized for 30 h under
similar conditions with "P-labelled (10 d pm ml", random-primed labelling system, Boehringer …
similar conditions with "P-labelled (10 d pm ml", random-primed labelling system, Boehringer …
Antipsychotic drug doses and neuroleptic/dopamine receptors
P Seeman, T Lee, M Chau-Wong, K Wong - Nature, 1976 - nature.com
ANTIPSYCHOTIC drugs, or neuroleptics, are thought to act by blocking dopamine receptors
in the nervous system 1–4 . Recent direct evidence, based on stereospecific binding assays, …
in the nervous system 1–4 . Recent direct evidence, based on stereospecific binding assays, …
Radioreceptor binding profile of the atypical antipsychotic olanzapine
…, RD Marsh, NA Moore, NC Tye, P Seeman… - …, 1996 - nature.com
The affinities of olanzapine, clozapine, haloperidol, and four potential antipsychotics were
compared on binding to the neuronal receptors of a number of neurotransmitters. In both rat …
compared on binding to the neuronal receptors of a number of neurotransmitters. In both rat …
Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
P Seeman, M Chau-Wong… - Proceedings of the …, 1975 - National Acad Sciences
In order to test the suggestion that antipsychotic drugs act by blocking dopamine receptors
in the brain, the direct effects of such neuroleptic drugs were tested on the stereospecific …
in the brain, the direct effects of such neuroleptic drugs were tested on the stereospecific …
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
RK Sunahara, HC Guan, BF O'Dowd, P Seeman… - Nature, 1991 - nature.com
DOPAMINE receptors belong to a superfamily of receptors that exert their biological effects
through guanine nucleotide-binding (G) proteins. Two main dopamine receptor subtypes …
through guanine nucleotide-binding (G) proteins. Two main dopamine receptor subtypes …
Multiple dopamine D4 receptor variants in the human population
… The Southern blots were probed with a "P-labelled 600-bp EcoRI-HinCl fragment coding for
the D4 cDNA isolated from the neuroepithelioma SK-N-MC", and washed at high stringency (…
the D4 cDNA isolated from the neuroepithelioma SK-N-MC", and washed at high stringency (…
Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons
P Seeman, T Lee - Science, 1975 - science.org
… Trans-thiothixene (P-4657A) is of the order of one-hundreth the potency of its cisisomer (I 7).
… 2, 1972); a complete list of these references is given by P. Seeman, in Antipsychotic Drugs, …
… 2, 1972); a complete list of these references is given by P. Seeman, in Antipsychotic Drugs, …