User profiles for Peter Metrakos

Peter Metrakos

Professor, Dept of Surgery, Faculty of Medicine, McGill University; Senior Scientist, RI …
Verified email at mcgill.ca
Cited by 6033

[HTML][HTML] Sunitinib malate for the treatment of pancreatic neuroendocrine tumors

…, C Lombard-Bohas, J Valle, P Metrakos… - … England Journal of …, 2011 - Mass Medical Soc
Background The multitargeted tyrosine kinase inhibitor sunitinib has shown activity against
pancreatic neuroendocrine tumors in preclinical models and phase 1 and 2 trials. Methods …

Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer

T Boutros, E Chevet, P Metrakos - Pharmacological reviews, 2008 - ASPET
Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1, DUSP1,
ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine dual-…

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

…, E Loyer, L Dirix, D Cunningham, P Metrakos… - Nature medicine, 2016 - nature.com
The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that
are poorly understood. Notably, instead of through the induction of angiogenesis, tumor …

Mechanical ventilation–induced diaphragm disuse in humans triggers autophagy

…, R Chaturvedi, SB Gottfried, P Metrakos… - American journal of …, 2010 - atsjournals.org
Rationale: Controlled mechanical ventilation (CMV) results in atrophy of the human diaphragm.
The autophagy-lysosome pathway (ALP) contributes to skeletal muscle proteolysis, but …

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy

AM Khatib, G Siegfried, M Chrétien, P Metrakos… - The American journal of …, 2002 - Elsevier
The mammalian subtilisin/kexin-like proprotein convertase (PC) family has been implicated
in the activation of a wide spectrum of proteins. These proteins are usually synthesized as …

[HTML][HTML] International consensus guidelines for scoring the histopathological growth patterns of liver metastasis

…, NC Bird, F Vidal-Vanaclocha, P Metrakos… - British journal of …, 2017 - nature.com
Background: Liver metastases present with distinct histopathological growth patterns (HGPs),
including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The …

[HTML][HTML] Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like …

…, A Prat, J Luis, M Chrétien, P Metrakos… - Journal of Biological …, 2001 - ASBMB
Proprotein convertases (PCs) of the subtilisin/kexin family are responsible for the activation
of prohormones, protrophic factors, and their receptors. We sought to determine whether loss …

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies

…, N Siddiqui, M Bhat, D Zammit, V Marcus, P Metrakos… - Cancer research, 2012 - AACR
Active-site mTOR inhibitors (asTORi) hold great promise for targeting dysregulated mTOR
signaling in cancer. Because of the multifaceted nature of mTORC1 signaling, identification of …

[PDF][PDF] Liver transplantation for incidental cholangiocarcinoma: analysis of the Canadian experience

…, D Marleau, K Peltekian, P Metrakos… - Liver …, 2005 - Wiley Online Library
Cholangiocarcinoma is a biliary tumor, which not infrequently complicates primary sclerosing
cholangitis. It carries a poor prognosis and, with the exception of carefully selected …

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

…, L Denis, RC Oliveira, P Metrakos… - British journal of …, 2022 - nature.com
The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of
liver metastases were established in 2017. Since then, numerous studies have applied these …