[HTML][HTML] Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2

…, F Lefoulon, JL Fauchere, P Delagrange… - Journal of Biological …, 2000 - ASBMB
The regulation of the circadian rhythm is relayed from the central nervous system to the
periphery by melatonin, a hormone synthesized at night in the pineal gland. Besides two …

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors

ML Dubocovich, P Delagrange, DN Krause… - Pharmacological …, 2010 - ASPET
The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …

Update on melatonin receptors: IUPHAR Review 20

R Jockers, P Delagrange… - British journal of …, 2016 - Wiley Online Library
Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR
superfamily. In mammals, two melatonin receptor subtypes exist ‐ MT 1 and MT 2 ‐ encoded …

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

…, JL Guillaume, C Couturier, P Delagrange… - The EMBO …, 2006 - embopress.org
One‐third of the ∼400 nonodorant G protein‐coupled receptors (GPCRs) are still orphans.
Although a considerable number of these receptors are likely to transduce cellular signals in …

Molecular tools to study melatonin pathways and actions

JA Boutin, V Audinot, G Ferry, P Delagrange - Trends in Pharmacological …, 2005 - cell.com
Melatonin, an indoleamine neurohormone that is synthesized mainly in the pineal gland
and derived from 5-HT, has many effects on a wide range of physio-pathological functions. …

Melatonin reduces body weight gain in Sprague Dawley rats with diet-induced obesity

…, M Desbazeille, A Bros, K Louche, P Delagrange… - …, 2003 - academic.oup.com
Melatonin is involved in the regulation of seasonal obesity in various species, including some
rodents. This involvement has been demonstrated in nonphotoperiodic rodents like rats, …

New selective ligands of human cloned melatonin MT1 and MT2 receptors

…, F Lefoulon, P Renard, P Delagrange… - Naunyn-Schmiedeberg's …, 2003 - Springer
Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts
its multiple roles mainly through two seven transmembrane domain, G-coupled receptors, …

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

…, WA Catterall, AP Davenport, P Delagrange… - Nucleic acids …, 2009 - academic.oup.com
The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical,
genetic, functional and anatomical information on the 354 nonsensory G protein-coupled …

Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers

MA Ayoub, A Levoye, P Delagrange, R Jockers - Molecular pharmacology, 2004 - ASPET
Heterodimerization has been documented for several members of the G protein-coupled
receptor (GPCR) superfamily, including the closely related MT 1 and MT 2 melatonin receptors. …

Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2

O Nosjean, JP Nicolas, F Klupsch, P Delagrange… - Biochemical …, 2001 - Elsevier
The neurohormone melatonin is the central switch of the circadian rhythm and presumably
exerts its activities through a series of receptors among which MT 1 and MT 2 have been …