ATP acts as a humoral mediator to control cell function extracellularly. The receptors that
mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the …

Body fluid homeostasis requires the release of arginine-vasopressin (AVP, an antidiuretic
hormone) from the neurohypophysis. This release is controlled by specific and highly sensitive …

Ionotropic ATP receptors are widely expressed in mammalian CNS. Despite extensive
functional characterization of neuronal homomeric P2X receptors in heterologous expression …

The absence of fragile X mental retardation protein results in the fragile X syndrome (FXS),
a common form of mental retardation associated with attention deficit, autistic behavior, and …

Chronic pain is a highly prevalent debilitating condition for which treatment options remain
limited for many patients. Ionotropic ATP signalling through excitatory and calcium‐…

P2X receptors are nonselective cation channels gated by extracellular ATP. Recombinant
mammalian P2X subunits assemble in homomeric ionotropic ATP receptors that differ by their …

: Small changes of extracellular pH activate depolarizing inward currents in most nociceptive
neurons. It has been recently proposed that acid sensitivity of sensory as well as central …

Objective: To investigate and measure the functional significance of altered P2Y12 expression
in the context of human microglia activation. Methods: We performed in vitro and in situ …

We report a novel model in which remote activation of peripheral nociceptive pathways in
transgenic mice is achieved optogenetically, without any external noxious stimulus or injury. …

P2X 7 is a subtype of ATP-gated channels that is highly expressed in astrocytes, microglia,
and other immune cells. Activation of P2X 7 purinoceptors by ATP or 3′-O-(4-benzoyl)-…