Dioxins are ubiquitous environmental contaminants that have attracted toxicological interest
not only for the potential risk they pose to human health but also because of their unique …

Mechanistic toxicology has predominantly been focused on adverse effects that are caused
by reactive metabolites or by reactive oxygen species. However, many important xenobiotics …

Dioxins are ubiquitous and persistent environmental contaminants whose background levels
are still reason for concern. There is mounting evidence from both epidemiological and …

Conventional biochemical and molecular techniques identified previously several genes
whose expression is regulated by the aryl hydrocarbon receptor (AHR). We sought to map the …

The European Commission asked EFSA for a scientific opinion on the risks for animal and
human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in feed and food. …

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent dioxin. There are exceptionally
wide inter- and intraspecies differences in sensitivity to TCDD toxicity with Han/Wistar (H/…

… data (R = 0.95) but a lower correlation of either of OpenArray (R = 0.48) or NanoString (…
that exhibited more variability with a moderate correlation (R = 0.55) with the NanoString data. …

Risk assessment of dioxins is currently based on induction of liver tumors in rats. The toxicity
of dioxins is characterized by large sensitivity differences among animal species and even …

We have previously demonstrated a more than 300‐fold difference in acute LD50 values for
2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) between male Long‐Evans (Turku AB; L‐E) …

The Ah receptor (AHR) is a fascinating and intriguing protein. Initially discovered in the
1970s as the mediator of a primarily adaptive response, induction of xenobiotic metabolizing …