Psychedelic drugs have a long history of use in healing ceremonies, but despite renewed
interest in their therapeutic potential, we continue to know very little about how they work in the …

This article explores the notion that Freudian constructs may have neurobiological substrates.
Specifically, we propose that Freud’s descriptions of the primary and secondary processes …

This paper formulates the action of psychedelics by integrating the free-energy principle
and entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics (…

Plant-based psychedelics, such as psilocybin, have an ancient history of medicinal use.
After the first English language report on LSD in 1950, psychedelics enjoyed a short-lived …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Background Psilocybin is a serotonin receptor agonist that occurs naturally in some mushroom
species. Recent studies have assessed the therapeutic potential of psilocybin for various …

… Carhart-Harris, RL et al. Neural correlates of the psychedelic state as determined by fMRI
studies with psilocybin. Proceedings of the National Academy of Sciences of the United States …

Microdosing is the practice of regularly using low doses of psychedelic drugs. Anecdotal
reports suggest that microdosing enhances well-being and cognition; however, such accounts …

… DS1 and Carhart-Harris et al10); thus, the subjective effects of psilocybin were robust
throughout the behavioural scan. The total duration of the behavioural scan was 18.5 min (370 …

… Carhart-Harris would also like to acknowledge that Robert Leech coined the term “the
entropic brain” when in conversation with him over the topic of his and David Nutt's psilocybin …