Depression, the most frequent psychiatric disorder following ischaemic stroke, negatively
affects survivals' functional outcome, response to rehabilitation and quality of life. Approximately…

Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may …

There is increasing evidence that affective disorders are associated with dysfunction of
neurotransmitter postsynaptic transduction pathways and that chronic treatment with clinically …

The tissutal concentrations of reduced glutathione (GSH) and the contents of some key
components in the electron transfer chain (namely ubiquinone, cytochromes b, c 1 , c, and aa 3 ) …

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most frequent neurodegenerative
disorders. Despite their pathophysiological and clinical differences, they share several …

The knowledge of coenzyme Q levels in tissues, organs, and subcellular compartments is of
outstanding interest. A wide amount of data regarding coenzyme Q distribution and …

Alterations in mitochondrial functions have been hypothesized to participate in the
pathogenesis of depression, because brain bioenergetic abnormalities have been detected in …

The catalytic properties of energy-utilizing ATPases enzyme systems related to ions homeostasis
were evaluated in different types of synaptic plasma membranes (SPM) and in somatic …

We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions [free
mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)] from three brain areas (…

Brain bioenergetic abnormalities in mood disorders were detected by neuroimaging in vivo
studies in humans. Because of the increasing importance of mitochondrial pathogenetic …