A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase, inhibition
of which effectively eliminates estrogen production. Aromatase inhibitors successfully …

Aromatase P450 (P450arom) is the key enzyme for biosynthesis of estrogen, which is an
essential hormone for the establishment and growth of endometriosis. There is no detectable …

I. Introduction SPECIALIZED strategies have evolved for controlling embryonic development.
In oviparous species, development of the embryo is dependent upon regulatory factors …

OBJECTIVE: To investigate the effects of 17β-estradiol (E 2 ) on cyclooxygenase-2 (COX-2)
expression and prostaglandin E 2 (PGE 2 ) synthesis in primary human uterine …

The purpose of this investigation was to identify the cellular origin, and the temporal and
regional characteristics of placental lactogen-I (PL-I) and placental lactogen-II (PL-II) expression …

In this report, we describe the isolation, molecular cloning, and characterization of a new
member of the prolactin (PRL)-growth hormone (GH) family expressed in rat decidual tissue. A …

The aromatase gene encodes the key enzyme for estrogen formation. Aromatase enzyme
inhibitors eliminate total body estrogen production and are highly effective therapeutics for …

The rat chorioallantoic placenta is comprised of two morphologically distinct regions: the
junctional zone and the labyrinth zone. The purpose of this investigation was to determine the …

Context: Uterine leiomyomata are common tumors that cause irregular uterine bleeding and
pregnancy loss and depend on estrogen for growth. Aromatase catalyzes the conversion of …

In breast cancer, a dense layer of undifferentiated fibroblasts is formed around malignant
breast epithelial cells and referred to as desmoplastic reaction. These cells provide structural …