Metalloproteinases and their inhibitors: regulators of wound healing

SE Gill, WC Parks - The international journal of biochemistry & cell biology, 2008 - Elsevier
Wound healing is a dynamic process that involves a coordinated response of many cell types
representing distinct tissue compartments and is fundamentally similar among tissue types. …

[HTML][HTML] The role of TIMPs in regulation of extracellular matrix proteolysis

V Arpino, M Brock, SE Gill - Matrix biology, 2015 - Elsevier
Tissue inhibitors of metalloproteinases (TIMPs), which inhibit matrix metalloproteinases (MMPs)
as well as the closely related, a disintegrin and metalloproteinases (ADAMs) and …

Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology

…, Y Eslambolchi, S Chopra, D Young, S Gill… - Pharmacological …, 2022 - ASPET
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole
by its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Pulmonary macrophage subpopulations in the induction and resolution of acute lung injury

LK Johnston, CR Rims, SE Gill, JK McGuire… - American journal of …, 2012 - atsjournals.org
Macrophages are key orchestrators of the inflammatory and repair responses in the lung,
and the diversity of their function is indicated by their polarized states and distinct …

Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury

C Schrimpf, C Xin, G Campanholle, SE Gill… - Journal of the …, 2012 - journals.lww.com
Kidney pericytes are progenitors of scar-forming interstitial myofibroblasts that appear after
injury. The function of kidney pericytes as microvascular cells and how these cells detach …

[HTML][HTML] Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo

SE Gill, M Rohan, S Mehta - Respiratory research, 2015 - Springer
Background Sepsis remains a common and serious condition with significant morbidity and
mortality due to multiple organ dysfunction, especially acute lung injury (ALI) and acute …

[HTML][HTML] Expression analysis of the entire MMP and TIMP gene families during mouse tissue development

RK Nuttall, CL Sampieri, CJ Pennington, SE Gill… - FEBS letters, 2004 - Elsevier
Matrix metalloproteinases (MMPs) and adamalysins (ADAMs) cleave many extracellular
proteins, including matrix, growth factors, and receptors. We profiled the RNA levels of every …

[HTML][HTML] Endothelial injury and glycocalyx degradation in critically ill coronavirus disease 2019 patients: implications for microvascular platelet aggregation

…, EK Patterson, M Slessarev, SE Gill… - Critical Care …, 2020 - journals.lww.com
Objectives: Coronavirus disease 2019 is caused by the novel severe acute respiratory syndrome
coronavirus 2 virus. Patients admitted to the ICU suffer from microvascular thrombosis, …

[HTML][HTML] Metabolomics profiling of critically ill coronavirus disease 2019 patients: identification of diagnostic and prognostic biomarkers

…, EK Patterson, DB O'Gorman, SE Gill… - Critical care …, 2020 - journals.lww.com
Objectives: Coronavirus disease 2019 continues to spread rapidly with high mortality. We
performed metabolomics profiling of critically ill coronavirus disease 2019 patients to …

Proteoglycans: key regulators of pulmonary inflammation and the innate immune response to lung infection

S Gill, TN Wight, CW Frevert - The Anatomical Record …, 2010 - Wiley Online Library
Exposure to viruses and bacteria results in lung infections and places a significant burden
on public health. The innate immune system is an early warning system that recognizes …