Gut microbiota are related to Parkinson's disease and clinical phenotype
…, E Pekkonen, E Haapaniemi, S Kaakkola… - Movement …, 2015 - Wiley Online Library
In the course of Parkinson's disease (PD), the enteric nervous system (ENS) and parasympathetic
nerves are amongst the structures earliest and most frequently affected by alpha‐…
nerves are amongst the structures earliest and most frequently affected by alpha‐…
Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors
PT Männistö, S Kaakkola - Pharmacological reviews, 1999 - ASPET
Axelrod et al.(1958) first described the enzyme-catalyzed O-methylation of catecholamines
and other catechols in the late 1950s. The enzyme responsible for the O-methylation, catechol…
and other catechols in the late 1950s. The enzyme responsible for the O-methylation, catechol…
A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
…, L Myllykangas, M Siitonen, A Raunio, S Kaakkola… - Neurobiology of …, 2014 - Elsevier
We describe the clinical, neuropathological, and genetic features of a Finnish patient with a
novel α-synuclein (SNCA) mutation A53E. The patient was clinically diagnosed with atypical …
novel α-synuclein (SNCA) mutation A53E. The patient was clinically diagnosed with atypical …
[PDF][PDF] Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin
…, A Löfgren, P Hackman, A Paetau, S Kaakkola… - The American Journal of …, 2005 - cell.com
Mutations in the catalytic subunit of the mitochondrial DNA polymerase γ (POLG) have been
found to be an important cause of neurological disease. Recently, we and collaborators …
found to be an important cause of neurological disease. Recently, we and collaborators …
A double blind, randomised, parallel group study to investigate the dose equivalence of Dysport® and Botox® in the treatment of cervical dystonia
T Odergren, H Hjaltason, S Kaakkola… - Journal of Neurology …, 1998 - jnnp.bmj.com
OBJECTIVE This study was designed to establish whether a ratio of three units of Dysport ®
is equivalent to one unit of Botox ® for the treatment of cervical dystonia. METHODS Patients …
is equivalent to one unit of Botox ® for the treatment of cervical dystonia. METHODS Patients …
POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement
…, P Luoma, M Rantamaki, A Al Memar, S Kaakkola… - Neurology, 2004 - AAN Enterprises
Objective: To identify POLG mutations in patients with sensory ataxia and CNS features.
Methods: The authors characterized clinical, laboratory, and molecular genetic features in eight …
Methods: The authors characterized clinical, laboratory, and molecular genetic features in eight …
Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease
S Kaakkola - Drugs, 2000 - Springer
When peripheral decarboxylation is blocked by carbidopa or benserazide, the main
metabolic pathway of levodopa is O-methylation by catechol-O-methyltransferase (COMT). …
metabolic pathway of levodopa is O-methylation by catechol-O-methyltransferase (COMT). …
Defective cortical drive to muscle in Parkinson's disease and its improvement with levodopa
We recorded whole‐scalp magnetoencephalographic (MEG) signals simultaneously with
surface electromyographic (EMG) activity from eight patients with Parkinson’s disease after …
surface electromyographic (EMG) activity from eight patients with Parkinson’s disease after …
Economic burden and quality of life impairment increase with severity of PD
T Keränen, S Kaakkola, K Sotaniemi… - Parkinsonism & related …, 2003 - Elsevier
Purpose. To define the interrelationship between cost-of-illness, quality of life (QoL) and
Parkinson's disease (PD) severity in a common patient management setting in Finland. Scope. …
Parkinson's disease (PD) severity in a common patient management setting in Finland. Scope. …
Laminin is induced in astrocytes of adult brain by injury.
P Liesi, S Kaakkola, D Dahl, A Vaheri - The EMBO journal, 1984 - embopress.org
Laminin is a high mol. wt. non‐collagenous matrix glycoprotein, confined in adult tissues to
basement membranes. In normal rat brain we found laminin mainly in vessel walls but, after …
basement membranes. In normal rat brain we found laminin mainly in vessel walls but, after …