User profiles for Stephanie I. Shiers

Stephanie Shiers

Verified email at utdallas.edu
Cited by 1516

Pharmacological manipulation of translation as a therapeutic target for chronic pain

MS Yousuf, SI Shiers, JJ Sahn, TJ Price - Pharmacological reviews, 2021 - ASPET
Dysfunction in regulation of mRNA translation is an increasingly recognized characteristic of
many diseases and disorders, including cancer, diabetes, autoimmunity, neurodegeneration…

Convergence of peptidergic and non‐peptidergic protein markers in the human dorsal root ganglion and spinal dorsal horn

SI Shiers, I Sankaranarayanan… - Journal of …, 2021 - Wiley Online Library
Peripheral sensory neurons are characterized by their size, molecular profiles, and physiological
responses to specific stimuli. In mouse, the peptidergic and non‐peptidergic subsets of …

Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice

KE Sadler, F Moehring, SI Shiers… - Science translational …, 2021 - science.org
Tactile and spontaneous pains are poorly managed symptoms of inflammatory and neuropathic
injury. Here, we found that transient receptor potential canonical 5 (TRPC5) is a chief …

Transient photoinactivation of cell membrane protein activity without genetic modification by molecular hyperthermia

P Kang, X Li, Y Liu, SI Shiers, H Xiong, M Giannotta… - ACS …, 2019 - ACS Publications
Precise manipulation of protein activity in living systems has broad applications in biomedical
sciences. However, it is challenging to use light to manipulate protein activity in living …

Activation of α6-containing GABAA receptors induces antinociception under physiological and pathological conditions

…, E Yarim, AM Islas-Espinoza, AE Félix-Leyva, SI Shiers… - Pain, 2023 - journals.lww.com
The loss of GABAergic inhibition is a mechanism that underlies neuropathic pain. Therefore,
rescuing the GABAergic inhibitory tone through the activation of GABA A receptors is a …

Limbic system development underlies the emergence of classical fear conditioning during the third and fourth weeks of life in the rat.

AL Deal, KJ Erickson, SI Shiers… - Behavioral …, 2016 - psycnet.apa.org
Classical fear conditioning creates an association between an aversive stimulus and a neutral
stimulus. Although the requisite neural circuitry is well understood in mature organisms, …

Studying human nociceptors: from fundamentals to clinic

…, AM Barry, M Comini, Y Li, PR Ray, S Shiers… - Brain, 2021 - academic.oup.com
Chronic pain affects one in five of the general population and is the third most important cause
of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate due …

[HTML][HTML] Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain

AJ McFarland, MS Yousuf, S Shiers, TJ Price - Pain reports, 2021 - journals.lww.com
SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors

D Tavares-Ferreira, S Shiers, PR Ray… - Science translational …, 2022 - science.org
Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …

Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization

S Shiers, RM Klein, TJ Price - Pain, 2020 - journals.lww.com
Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …