IT is now more than 30 years since Addis suggested that protein intake be restricted in patients
with chronic renal insufficiency. His aim was not to reduce uremic symptoms but rather to …

The meaning of uremia, which refers to the illness accompanying kidney failure that is
unexplained by derangements in extracellular volume, inorganic ion concentrations, or lack of …

THE process of urine formation begins at the walls of the glomerular capillaries with the
separation of as much as a third of the plasma entering the glomeruli of each kidney into a …

… Hostetter , Norbert Lameire , Garabed Eknoyan … D., MD, Germany; Thomas Hostetter, MD,
United States; Tazeen Jafar, MB, BS, MPH, Pakistan; Vivekanand Jha, MD, India; Cynda-Ann …

Micropuncture studies were performed in three groups of male Munich-Wistar rats 1 wk after
surgery: group I, eight control rats that underwent laparotomy and were fed a normal diet; …

… Hostetter et a! … Hostetter et a! … TH Host etter, Laboratoiy of Kidney and Electrolyte
Physiology. Brigham and Women's Hospital, 75 Francis St., Boston, Massachusetts 02115, USA …

The incidence of kidney failure treatment in the United States increased 57% from 1991 to
2000. Chronic kidney disease (CKD) prevalence was 11% among US adults surveyed in …

The human end-stage kidney and its experimental analogue, the remnant kidney in the rat,
exhibit widespread tubulo-interstitial disease. We investigated whether the pathogenesis of …

The renin-angiotensin-aldosterone system (RAAS) participates in the injury sustained by the
remnant kidney. Our studies assessed the importance of aldosterone in that model and the …

Microbes in the colon produce compounds, normally excreted by the kidneys, which are
potential uremic toxins. Although p-cresol sulfate and indoxyl sulfate are well studied examples, …