Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular
health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV-…

The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in
animal models of diabetes and obesity. Using quantitative RT-PCR, we here show that the …

Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as targets …

Background & Aims Nonalcoholic fatty liver disease is a common consequence of human
and rodent obesity. Disruptions in lipid metabolism lead to accumulation of triglycerides and …

Objective Excess ethanol consumption has serious pathologic consequences. In humans,
repeated episodes of binge drinking can lead to liver damage and have adverse effects on …

Coordinated regulation of bile acid biosynthesis, the predominant pathway for hepatic
cholesterol catabolism, is mediated by few key nuclear receptors including the orphan receptors …

Thyroid hormones [predominantly 3,5,3′-triiodo-l-thyronine (T 3 )] regulate cholesterol and
lipoprotein metabolism, but cardiac effects restrict their use as hypolipidemic drugs. T 3 …

Interruption of the enterohepatic circulation of bile acids increases cholesterol catabolism,
thereby stimulating hepatic cholesterol synthesis from acetate. We hypothesized that such …

Cholesterol elimination from the body involves reverse cholesterol transport from peripheral
tissues in which the elimination of high density lipoprotein (HDL) and low density lipoprotein …

Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is induced in energy-starved
conditions and is a key regulator of energy homeostasis. This makes PGC-1α an …