User profiles for Tom J. J. Schirris
Tom SchirrisAssistant Professor Radboud University medical center Verified email at radboudumc.nl Cited by 988 |
Brothers in arms: ABCA1-and ABCG1-mediated cholesterol efflux as promising targets in cardiovascular disease treatment
…, GA Rongen, FGM Russel, TJJ Schirris - Pharmacological …, 2020 - ASPET
Atherosclerosis is a leading cause of cardiovascular disease worldwide, and hypercholesterolemia
is a major risk factor. Preventive treatments mainly focus on the effective reduction of …
is a major risk factor. Preventive treatments mainly focus on the effective reduction of …
Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention
…, MJW Adjobo-Hermans, J Keijer, TJJ Schirris… - Brain, 2022 - academic.oup.com
Mitochondria are small cellular constituents that generate cellular energy (ATP) by oxidative
phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous …
phosphorylation (OXPHOS). Dysfunction of these organelles is linked to a heterogeneous …
[PDF][PDF] Statin-induced myopathy is associated with mitochondrial complex III inhibition
Cholesterol-lowering statins effectively reduce the risk of major cardiovascular events.
Myopathy is the most important adverse effect, but its underlying mechanism remains enigmatic. …
Myopathy is the most important adverse effect, but its underlying mechanism remains enigmatic. …
Time to change: A systems pharmacology approach to disentangle mechanisms of drug-induced mitochondrial toxicity
An increasing number of commonly prescribed drugs are known to interfere with mitochondrial
function, which is associated with almost half of all Food and Drug Administration black …
function, which is associated with almost half of all Food and Drug Administration black …
[HTML][HTML] Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia
…, M Schmidts, R Roepman, TJJ Schirris… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Background Kidney disease modeling and assessment of drug-induced kidney injury can
be advanced using three-dimensional (3D) microfluidic models that recapitulate in vivo …
be advanced using three-dimensional (3D) microfluidic models that recapitulate in vivo …
Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells
WMA Westerink, TJJ Schirris, GJ Horbach… - … /Genetic Toxicology and …, 2011 - Elsevier
In the present study an automated image analysis assisted in vitro micronucleus assay was
developed with the rodent cell line CHO-k1 and the human hepatoma cell line HepG2, which …
developed with the rodent cell line CHO-k1 and the human hepatoma cell line HepG2, which …
Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism
NAE Allard, TJJ Schirris, RJ Verheggen… - The Journal of …, 2018 - academic.oup.com
… Tom JJ Schirris , Tom JJ Schirris … Neeltje AE Allard, Tom JJ Schirris, Rebecca J Verheggen,
Frans GM Russel, Richard J Rodenburg, Jan AM Smeitink, Paul D Thompson, Maria TE …
Frans GM Russel, Richard J Rodenburg, Jan AM Smeitink, Paul D Thompson, Maria TE …
Safety of drug use in patients with a primary mitochondrial disease: an international Delphi‐based consensus
…, FGM Russel, KN Varhaug, TJJ Schirris… - Journal of Inherited …, 2020 - Wiley Online Library
Clinical guidance is often sought when prescribing drugs for patients with primary
mitochondrial disease. Theoretical considerations concerning drug safety in patients with …
mitochondrial disease. Theoretical considerations concerning drug safety in patients with …
[PDF][PDF] Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux
DC Liemburg-Apers, TJJ Schirris, FGM Russel… - Biophysical …, 2015 - cell.com
ATP can be produced in the cytosol by glycolytic conversion of glucose (GLC) into pyruvate.
The latter can be metabolized into lactate, which is released by the cell, or taken up by …
The latter can be metabolized into lactate, which is released by the cell, or taken up by …
Statin lactonization by uridine 5′-diphospho-glucuronosyltransferases (UGTs)
TJJ Schirris, T Ritschel, A Bilos… - Molecular …, 2015 - ACS Publications
Statins are cholesterol-lowering drugs that have proven to be effective in lowering the risk of
major cardiovascular events. Although well tolerated, statin-induced myopathies are the …
major cardiovascular events. Although well tolerated, statin-induced myopathies are the …