Recent developments of HDAC inhibitors: Emerging indications and novel molecules

…, J Jonsson, VN Chubarev, VV Tarasov… - British journal of …, 2021 - Wiley Online Library
The histone deacetylase (HDAC) enzymes, a class of epigenetic regulators, are historically
well established as attractive therapeutic targets. During investigation of trends within clinical …

[HTML][HTML] Advances in the development of new biomarkers for Alzheimer's disease

…, AA Shalimova, VN Chubarev, VV Tarasov… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the
most common type of neurodegenerative dementia. The prevalence of AD is expected to …

[HTML][HTML] Nanoparticles in clinical trials: Analysis of clinical trials, FDA approvals and use for COVID-19 vaccines

…, AV Sokolov, VN Chubarev, VV Tarasov… - International journal of …, 2023 - mdpi.com
Nanoparticles are heterologous small composites that are usually between 1 and 100
nanometers in size. They are applied in many areas of medicine with one of them being drug …

[HTML][HTML] Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum …

…, GM Ashraf, A Alsalme, MF Al-Ajmi, VV Tarasov… - Scientific reports, 2016 - nature.com
Bacterial spoilage of food products is regulated by density dependent communication system
called quorum sensing (QS). QS control biofilm formation in numerous food pathogens and …

[HTML][HTML] Sleep disorders associated with Alzheimer's disease: a perspective

…, MF Ávila-Rodriguez, NS Yarla, VV Tarasov… - Frontiers in …, 2018 - frontiersin.org
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of
Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative …

The possibility of an infectious etiology of Alzheimer disease

GM Ashraf, VV Tarasov, A Makhmutovа… - Molecular …, 2019 - Springer
Over the past three decades, there has been constant postulation regarding the infectious
etiology of Alzheimer disease (AD), which in turn suggests the vital role of various infectious …

Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target

…, M Friedemann, M Menschikowski, VV Tarasov… - Pharmacology & …, 2020 - Elsevier
Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo

…, AA Svistunov, ML Maksimov, VV Tarasov… - Drug design …, 2018 - Taylor & Francis
Cytochrome (CYP) 450 isoenzymes are the basic enzymes involved in Phase I biotransformation.
The most important role in biotransformation belongs to CYP3A4, CYP2D6, CYP2C9, …

Extracellular vesicles in cancer nanomedicine

VV Tarasov, AA Svistunov, VN Chubarev… - Seminars in cancer …, 2021 - Elsevier
To date, a lot of nanotechnological optitions are available for targeted drug delivery.
Extracellular vesicles (EVs) are membrane structures that cells use for storage, transport, …

[HTML][HTML] Treatment of ADHD: Drugs, psychological therapies, devices, complementary and alternative methods as well as the trends in clinical trials

…, AV Sokolov, VN Chubarev, VV Tarasov… - Frontiers in …, 2022 - frontiersin.org
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental
disorders having a high influence on social interactions. The number of approved …