Prostanoids are the cyclooxygenase metabolites of arachidonic acid and include prostaglandin
(PG) D 2 , PGE 2 , PGF 2α , PGI 2 , and thromboxne A 2 . They are synthesized and …

Diabetes, a disease in which the body does not produce or use insulin properly, is a serious
global health problem 1 , 2 , 3 . Gut polypeptides secreted in response to food intake, such …

Prostaglandin (PG) E 2 exerts its actions by acting on a group of G-protein-coupled receptors
(GPCRs). There are four GPCRs responding to PGE 2 designated subtypes EP1, EP2, EP3…

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

Mice lacking the gene encoding the receptor for prostaglandin F 2α (FP) developed
normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice …

Allergic asthma is caused by the aberrant expansion in the lung of T helper cells that produce
type 2 (T H 2) cytokines and is characterized by infiltration of eosinophils and bronchial …

Prostanoids are a group of bioactive lipids working as local mediators 1 and include D, E, F
and I types of prostaglandins (PGs) and thromboxanes. Prostacyclin (PGI 2 ) acts on platelets …

Fever, a hallmark of disease, is elicited by exogenous pyrogens, that is, cellular components,
such as lipopolysaccharide (LPS), of infectious organisms, as well as by non-infectious …

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …

Arachidonic acid is metabolized to prostaglandin H 2 (PGH 2 ) by cyclooxygenase (COX).
COX-2, the inducible COX isozyme, has a key role in intestinal polyposis 1 , 2 . Among the …