The P2X7 Receptor Channel Pore Dilates under Physiological Ion Conditions
Z Yan, S Li, Z Liang, M Tomic… - The Journal of general …, 2008 - rupress.org
Activation of the purinergic P2X 7 receptor leads to the rapid opening of an integral ion channel
that is permeable to small cations. This is followed by a gradual increase in permeability …
that is permeable to small cations. This is followed by a gradual increase in permeability …
Activation and regulation of purinergic P2X receptor channels
Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
Experimental characterization and mathematical modeling of P2X7 receptor channel gating
The P2X7 receptor is a trimeric channel with three binding sites for ATP, but how the occupancy
of these sites affects gating is still not understood. Here we show that naive receptors …
of these sites affects gating is still not understood. Here we show that naive receptors …
Calcium-dependent block of P2X7 receptor channel function is allosteric
Among purinergic P2X receptor (P2XR) channels, the P2X7R exhibits the most complex
gating kinetics; the binding of orthosteric agonists at the ectodomain induces a conformational …
gating kinetics; the binding of orthosteric agonists at the ectodomain induces a conformational …
[PDF][PDF] Dual gating mechanism and function of P2X7 receptor channels
The ATP-gated P2X7 receptor channel (P2X7R) operates as a cytolytic and apoptotic receptor
but also controls sustained cellular responses, including cell growth and proliferation. …
but also controls sustained cellular responses, including cell growth and proliferation. …
Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation
I Jelínková, Z Yan, Z Liang, S Moonat… - Biochemical and …, 2006 - Elsevier
Ivermectin (IVM) applied extracellularly increases the sensitivity of P2X 4 receptor (P2X 4 R)
to ATP, enhances the maximum current amplitudes, and greatly prolongs the deactivation …
to ATP, enhances the maximum current amplitudes, and greatly prolongs the deactivation …
Structural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells
SS Stojilkovic, Z Yan, T Obsil, H Zemkova - Cellular and molecular …, 2010 - Springer
The P2X4 receptor (P2X4R) is a member of a family of ATP-gated cation channels that are
composed of three subunits. Each subunit has two transmembrane (TM) domains linked by a …
composed of three subunits. Each subunit has two transmembrane (TM) domains linked by a …
Expression and roles of pannexins in ATP release in the pituitary gland
S Li, I Bjelobaba, Z Yan, M Kucka, M Tomić… - …, 2011 - academic.oup.com
Pannexins are a newly discovered three-member family of proteins expressed in the brain
and peripheral tissues that belong to the superfamily of gap junction proteins. However, in …
and peripheral tissues that belong to the superfamily of gap junction proteins. However, in …
[HTML][HTML] TRPV1 channels are functionally coupled with BK (mSlo1) channels in rat dorsal root ganglion (DRG) neurons
The transient receptor potential vanilloid receptor 1 (TRPV1) channel is a nonselective
cation channel activated by a variety of exogenous and endogenous physical and chemical …
cation channel activated by a variety of exogenous and endogenous physical and chemical …
Role of aromatic and charged ectodomain residues in the P2X4 receptor functions
H Zemkova, Z Yan, Z Liang, I Jelinkova… - Journal of …, 2007 - Wiley Online Library
The localization of ATP binding site(s) at P2X receptors and the molecular rearrangements
associated with opening and closing of channels are still not well understood. At P2X 4 …
associated with opening and closing of channels are still not well understood. At P2X 4 …