Abstract
1. Aggregation influences the toxicity of sympathomimetic amines in mice.
2. As the area per mouse increases, the toxicity decreases for mice confined in a group.
3. If the area per mouse is kept. constant at approximately 50 sq. cm., the presence of [9] other mice markedly increases the toxicity of these drugs.
4. Environmental temperature greatly influences the degree of mutual excitation and thus modifies the effect of aggregation on toxicity.
Footnotes
- Received January 24, 1946.
- 1946 by The American Society for Pharmacology and Experimental Therapeutics