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Name Receptor Code SWISSPROT Main Agonists Main Functions CXC subgroup CXCR1 2.1:CHK:1:CXC1: P25024 CXCL8 Neutrophil migration; innate immunity; acute inflammation CXCR2 2.1:CHK:2:CXC2: P25025 CXCL1–3; CXCL5–8 Neutrophil migration; innate immunity; acute inflammation; angiogenesis CXCR3 2.1:CHK:3:CXC3: P49682 CXCL9–11 T cell migration; adaptive immunity; Th1 inflammation CXCR4 2.1:CHK:4:CXC4: P30991 CXCL12 B cell lymphopoiesis; bone marrow myelopoiesis; central nervous system and vascular development; HIV infection CXCR5 2.1:CHK:5:CXC5: P32302 CXCL13 B cell trafficking; lymphoid development CXCR6 2.1:CHK:19:CXC6: O00574 CXCL16 T cell migration CC subgroup CCR1 2.1:CHK:6:CC1: P32246 CCL3, CCL5, CCL7, CCL8, CCL13–16, CCL23 T cell and monocyte migration; innate and adaptive immunity; inflammation CCR2 2.1:CHK:7:CC2: P41597 CCL2, CCL7, CCL8, CCL13 T cell and monocyte migration; innate and adaptive immunity; Th1 inflammation CCR3 2.1:CHK:8:CC3: P51677 CCL5, CCL7; CCL8; CCL11, CCL13; CCL15; CCL24; CCL26 Eosinophil, basophil, and T cell migration; allergic inflammation CCR4 2.1:CHK:9:CC4: P51679 CCL17, CCL22 T cell and monocyte migration; allergic inflammation CCR5 2.1:CHK:10:CC5: P51681 CCL3; CCL4; CCL5; CCL8, CCL14 T cell and monocyte migration; innate and adaptive immunity; HIV infection CCR6 2.1:CHK:11:CC6: P51684 CCL20 Dendritic cell migration CCR7 2.1:CHK:12:CC7: P32248 CCL19, CCL21 T cell and dendritic cell migration; lymphoid development; primary immune response CCR8 2.1:CHK:13:CC8: P51685 CCL1, CCL4; CCL17 T cell trafficking CCR9 2.1:CHK:14:CC9: P51686 CCL25 T cell homing to gut CCR10 2.1:CHK:15:CC10: P46092 CCL26–28 T cell homing to skin CX3C and C subgroups CX3CR1 2.1:CHK:17:CX3C1 P49238 CX3CL1 T cell and NK cell trafficking and adhesion; innate and adaptive immunity; Th1 inflammation XCR1 2.1:CHK:18:XC1: P46094 XCL1–2 T cell trafficking
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