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- Article
- Abstract
- I. Introduction
- II. Phosphoinositide 3-Kinase Signaling Pathway
- III. Role of Phosphoinositide 3-Kinases γ and δ in the Immune System
- IV. Cooperation between Phosphoinositide 3-Kinase Isoforms in the Immune Response
- V. Emergence of Chemical Tools to Target Phosphoinositide 3-Kinase Signaling
- VI. Development of Phosphoinositide 3-Kinase Inhibitors with Which to Target the Immune System
- VII. Therapeutic Potential of Inhibitors Targeting Phosphoinositide 3-Kinase γ and δ For Immune Disorders
- VIII. Beyond the Class I Phosphoinositide 3-Kinase Isoforms: Increased Understanding of a Role for Class II and III Phosphoinositide 3-Kinases in the Immune System
- IX. SH2-Domain Containing Inositol-5-phosphatase-1: An Alternative Target for Selective Modulation of Phosphoinositide 3-Kinase in the Immune System
- X. Manipulation of SH2-Domain Containing Inositol-5-phosphatase-1 Catalytic Activity with Small Molecules
- XI. Conclusions
- Acknowledgments
- Authorship Contributions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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