Review ArticleReview Article
Insights into the Neurobiology of the Nicotinic Cholinergic System and Nicotine Addiction from Mice Expressing Nicotinic Receptors Harboring Gain-of-Function Mutations
Ryan M. Drenan and Henry A. Lester
Burt M. Sharp, ASSOCIATE EDITOR, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana (R.M.D.); and Division of Biology, California Institute of Technology, Pasadena, California (H.A.L.)
Pharmacological Reviews October 2012, 64 (4) 869-879; DOI: https://doi.org/10.1124/pr.111.004671
Ryan M. Drenan
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana (R.M.D.); and Division of Biology, California Institute of Technology, Pasadena, California (H.A.L.)
Henry A. Lester
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana (R.M.D.); and Division of Biology, California Institute of Technology, Pasadena, California (H.A.L.)
Burt M. Sharp
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana (R.M.D.); and Division of Biology, California Institute of Technology, Pasadena, California (H.A.L.)
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
MICE EXPRESSING GAIN-OF-FUNCTION NACHRS
Ryan M. Drenan and Henry A. Lester
Pharmacological Reviews October 1, 2012, 64 (4) 869-879; DOI: https://doi.org/10.1124/pr.111.004671
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- Article
- Abstract
- I. Introduction
- II. Critical Issues in the Production of Useful Nicotinic Acetylcholine Receptor Gain-of-Function Mice
- III. Critical Molecular, Neurochemical, and Behavioral Observations from Mice Expressing Hypersensitive Nicotinic Acetylcholine Receptor Subunits
- IV. Conceptual Advances in Understanding Dopamine Reinforcement Circuitry
- V. Implications for Development of Therapeutics
- Acknowledgments
- Authorship Contributions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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