Review ArticleReview Article
The Expanding Roles of Gβγ Subunits in G Protein–Coupled Receptor Signaling and Drug Action
Shahriar M. Khan, Rory Sleno, Sarah Gora, Peter Zylbergold, Jean-Philippe Laverdure, Jean-Claude Labbé, Gregory J. Miller and Terence E. Hébert
Eric L. Barker, ASSOCIATE EDITOR, Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Pharmacological Reviews April 2013, 65 (2) 545-577; DOI: https://doi.org/10.1124/pr.111.005603
Shahriar M. Khan
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Rory Sleno
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Sarah Gora
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Peter Zylbergold
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Jean-Philippe Laverdure
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Jean-Claude Labbé
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Gregory J. Miller
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Terence E. Hébert
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Eric L. Barker
Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada (S.M.K., R.S., S.G., P.Z., G.J.M., T.E.H.); Institut de Recherche en Immunologie et en Cancérologie, (J.-P.L., J.-C.L.), and Department of Pathology and Cell Biology (J.-C.L.), Université de Montréal, Montréal, Québec, Canada; and Department of Chemistry, Catholic University of America, Washington, DC (G.J.M.)
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Novel Facets of Gβγ Signaling
Shahriar M. Khan, Rory Sleno, Sarah Gora, Peter Zylbergold, Jean-Philippe Laverdure, Jean-Claude Labbé, Gregory J. Miller and Terence E. Hébert
Pharmacological Reviews April 1, 2013, 65 (2) 545-577; DOI: https://doi.org/10.1124/pr.111.005603
Review ArticleReview Article
Novel Facets of Gβγ Signaling
Shahriar M. Khan, Rory Sleno, Sarah Gora, Peter Zylbergold, Jean-Philippe Laverdure, Jean-Claude Labbé, Gregory J. Miller and Terence E. Hébert
Pharmacological Reviews April 1, 2013, 65 (2) 545-577; DOI: https://doi.org/10.1124/pr.111.005603
Jump to section
- Article
- Abstract
- I. Introduction
- II. Diversity and Phylogeny of Gβγ Subunits
- III. Canonical Signaling Regulated by Gβγ Subunits
- IV. Noncanonical Effectors of Gβγ Signaling
- V. Other Effectors
- VI. Phenotypes Associated with Knockout and Knockdown of Gβ and Gγ Subunits
- VII. Assembly of Gβγ Subunits
- VIII. Pharmacological Targeting of Gβγ Subunits
- IX. Conclusion and Future Directions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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