Review ArticleReview Article
Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions
Janne T. Backman, Anne M. Filppula, Mikko Niemi and Pertti J. Neuvonen
Markku Koulu, ASSOCIATE EDITOR, Department of Clinical Pharmacology, University of Helsinki (J.T.B., A.M.F., M.N., P.J.N.), and Helsinki University Hospital, Helsinki, Finland (J.T.B., M.N., P.J.N.)
Pharmacological Reviews January 2016, 68 (1) 168-241; DOI: https://doi.org/10.1124/pr.115.011411
Janne T. Backman
Department of Clinical Pharmacology, University of Helsinki (J.T.B., A.M.F., M.N., P.J.N.), and Helsinki University Hospital, Helsinki, Finland (J.T.B., M.N., P.J.N.)
Anne M. Filppula
Department of Clinical Pharmacology, University of Helsinki (J.T.B., A.M.F., M.N., P.J.N.), and Helsinki University Hospital, Helsinki, Finland (J.T.B., M.N., P.J.N.)
Mikko Niemi
Department of Clinical Pharmacology, University of Helsinki (J.T.B., A.M.F., M.N., P.J.N.), and Helsinki University Hospital, Helsinki, Finland (J.T.B., M.N., P.J.N.)
Pertti J. Neuvonen
Department of Clinical Pharmacology, University of Helsinki (J.T.B., A.M.F., M.N., P.J.N.), and Helsinki University Hospital, Helsinki, Finland (J.T.B., M.N., P.J.N.)
Markku Koulu
Department of Clinical Pharmacology, University of Helsinki (J.T.B., A.M.F., M.N., P.J.N.), and Helsinki University Hospital, Helsinki, Finland (J.T.B., M.N., P.J.N.)
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Role of CYP2C8 in Drug Metabolism and Interactions
Janne T. Backman, Anne M. Filppula, Mikko Niemi and Pertti J. Neuvonen
Pharmacological Reviews January 1, 2016, 68 (1) 168-241; DOI: https://doi.org/10.1124/pr.115.011411
Jump to section
- Article
- Abstract
- I. Introduction
- II. Basic Characteristics of Cytochrome P450 2C8
- III. Substrates of Cytochrome P450 2C8
- IV. Pharmacogenetics
- V. In Vitro Inhibition and Induction of Cytochrome P450 2C8
- VI. Clinical Drug Interactions Mediated via Cytochrome P450 2C8
- VII. Points to Consider When Investigating Cytochrome P450 2C8-Mediated Drug Metabolism and Interactions
- VIII. Conclusions and Future Prospects
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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