Review ArticleReview Article
Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications
Michael J. Lucido, Mandy Bekhbat, David R. Goldsmith, Michael T. Treadway, Ebrahim Haroon, Jennifer C. Felger and Andrew H. Miller
Robert Dantzer, ASSOCIATE EDITOR
Pharmacological Reviews July 2021, 73 (3) 1084-1117; DOI: https://doi.org/10.1124/pharmrev.120.000043
Michael J. Lucido
Emory Behavioral Immunology Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia (M.J.L., M.B., D.R.G., E.H., J.C.F., A.H.M.); and Department of Psychology, Emory University, Atlanta, Georgia (M.T.T.)
Mandy Bekhbat
Emory Behavioral Immunology Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia (M.J.L., M.B., D.R.G., E.H., J.C.F., A.H.M.); and Department of Psychology, Emory University, Atlanta, Georgia (M.T.T.)
David R. Goldsmith
Emory Behavioral Immunology Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia (M.J.L., M.B., D.R.G., E.H., J.C.F., A.H.M.); and Department of Psychology, Emory University, Atlanta, Georgia (M.T.T.)
Michael T. Treadway
Emory Behavioral Immunology Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia (M.J.L., M.B., D.R.G., E.H., J.C.F., A.H.M.); and Department of Psychology, Emory University, Atlanta, Georgia (M.T.T.)
Ebrahim Haroon
Emory Behavioral Immunology Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia (M.J.L., M.B., D.R.G., E.H., J.C.F., A.H.M.); and Department of Psychology, Emory University, Atlanta, Georgia (M.T.T.)
Jennifer C. Felger
Emory Behavioral Immunology Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia (M.J.L., M.B., D.R.G., E.H., J.C.F., A.H.M.); and Department of Psychology, Emory University, Atlanta, Georgia (M.T.T.)
Andrew H. Miller
Emory Behavioral Immunology Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia (M.J.L., M.B., D.R.G., E.H., J.C.F., A.H.M.); and Department of Psychology, Emory University, Atlanta, Georgia (M.T.T.)
Robert Dantzer
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Inflammation and Anhedonia: Pharmacological Implications
Michael J. Lucido, Mandy Bekhbat, David R. Goldsmith, Michael T. Treadway, Ebrahim Haroon, Jennifer C. Felger and Andrew H. Miller
Pharmacological Reviews July 1, 2021, 73 (3) 1084-1117; DOI: https://doi.org/10.1124/pharmrev.120.000043
Review ArticleReview Article
Inflammation and Anhedonia: Pharmacological Implications
Michael J. Lucido, Mandy Bekhbat, David R. Goldsmith, Michael T. Treadway, Ebrahim Haroon, Jennifer C. Felger and Andrew H. Miller
Pharmacological Reviews July 1, 2021, 73 (3) 1084-1117; DOI: https://doi.org/10.1124/pharmrev.120.000043
Jump to section
- Article
- Visual Overview
- Abstract
- I. Introduction
- II. Inflammation in Depression
- III. Mechanisms by which Inflammation Leads to Anhedonia
- IV. Metabolism, Inflammation, and Anhedonia
- V. Access of Inflammatory Molecules to Reward-Related Brain Regions
- VI. Evolutionary Concepts Related to Anhedonia and the Immune System
- VII. Translational Implications: Treatment Targets
- VIII. Anti-Inflammatory Trial Failures
- IX. Summary
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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