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Article

International Union of Pharmacology XLIV. Nomenclature for the Oxoeicosanoid Receptor

Centre National de la Recherche Scientifique UMR 7131, Hôpital Broussais, Bâtiment Les Mariniers, Paris, France (C.B.); Unit for Experimental Asthma and Allergy, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.-E.D); Harvard Medical School, Brigham and Woman's Hospital, Boston, Massachussetts (J.M.D.); Department of Pharmacology, Merck & Co., West Point, Pennsylvania (J.F.E.); GlaxoSmithKline, King of Prussia, Pennsylvania (D.W.P.H.); Division of Molecular Pharmacology, Pharmacological Sciences, Milan, Italy (G.E.R.); Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia Research Laboratory, Brigham and Woman's Hospital/Harvard Medical School, Boston, Massachusetts (C.N.S.); and Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Bunkyo-Ko, Tokyo, Japan (T.S., T.Y.)

Abstract

I. Overview

II. Introduction

III. Biosynthesis of Oxoeicosanoids

A. Cofactors for Oxoeicosanoid Formation

B. Cellular Production of Oxoeicoanoids

IV. Nomenclature for Oxoeicosanoid Receptors

V. Molecular Characteristics of Oxoeicosanoid Receptors

VI. Significance of Oxoeicosanoid Receptors

VII. Conclusion

Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that have been intimately linked with cellular migration. These metabolites are not only potent chemotaxins but also elicit oxygen radical production as well as induce secretory events in different cells. The most potent native ligand reported is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), and the cell membrane receptor activated has now been cloned. This receptor is distinct from those receptors activated by either the prostaglandins or the leukotrienes. The purpose of this review is to briefly summarize the molecular evidence and highlight the significance of this receptor. In addition, an official nomenclature for this oxoeicosanoid receptor is proposed.

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